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73032AST

Supelco

Astec® CHIRALDEX G-TA Capillary GC Column

L × I.D. 20 m × 0.25 mm, df 0.12 μm

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UNSPSC Code:
41115710
NACRES:
SB.54

material

fused silica

Quality Level

description

GC capillary column

packaging

pkg of 1 ea

parameter

-10-180 °C temperature (isothermal or programmed)

Beta value

500

df

0.12 μm

technique(s)

gas chromatography (GC): suitable

L × I.D.

20 m × 0.25 mm

matrix active group

non-bonded; 2,6-di-O-pentyl-3-trifluoroacetyl derivative of γ-cyclodextrin phase

application(s)

agriculture
chemicals and industrial polymers
cleaning products
clinical
cosmetics
environmental
flavors and fragrances
food and beverages
forensics and toxicology
life science and biopharma
personal care
pharmaceutical (small molecule)

column type

capillary chiral

separation technique

chiral

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General description

Astec® CHIRALDEX G-TA is the first choice in the Group 1 CSPs (Surface Interactions, Complex Derivatives). This phase has been shown to be the most broadly-selective phase for the pharmaceutical industry, especially for the analysis of chiral intermediates and drug studies in various stages of clinical trials. Separations occur without the inclusion mechanism and are typically faster and more efficient than most chiral stationary phases. G-TA has also been used to separate parent drug enantiomers and their metabolites. G-TA has its highest selectivity for oxygen-containing analytes like alcohols, diols and polyols as the free alcohol and as an acyl derivative; amines as acyl derivatives; amino alcohols, halogens (Cl>Br>F), amino acids, hydroxy acids, lactones, furans and pyrans. It is also highly selective for halogenated compounds.

Chem/Phys Resistance

Temp. Limits:
  • -10 °C to 180 °C isothermal and programmed

Other Notes

We offer a variety of chromatography accessories including analytical syringes

Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIRALDEX is a trademark of Sigma-Aldrich Co. LLC

Regulatory Information

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

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    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the regeneration procedure for Chiraldex TA columns? 

    The regeneration procedure for ChiraldexTA columns is located in Supelco brochure, T407123 (JCH), A Guide to Using Cyclodextrin Bonded Phases for Chiral Separations by Capillary Gas Chromatography, on pages 8 and 9.  These pages are attached.

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The synthesis of enantioenriched a-hydroxy esters
Gu, Xin, et al.
Tetrahedron Asymmetry, 25 (24), 1573-1580 (2014)
Organocatalysis using protonated 1,2-diamino-1,2-diphenylethane for asymmetric Diels?Alder reaction
Hoon Kim, Kyoung, et al.
Tetrahedron Letters, 46 (36), 5991-5994 (2005)
Isolation of racemic 2,4-pentanediol and 2,5-hexanediol from commercial mixtures of racemic and meso isomers by way of cyclic sulfites.
Caron, Gaetan; Kazlauskas, R.J.
Tetrahedron Asymmetry, 5 (4), 657-664 (1994)
The asymmetric hydrogenation of 2-phenethylacrylic acid as the key step for the enantioselective synthesis of Citralis Nitrile?
Scrivanti, Alberto, et al.
Tetrahedron Letters, 47 (52), 9261-9265 (2006)
Asymmetric conjugate addition to alkylidene malonates
Alexakis, Alexandre; Benhaim, Cyril;
Tetrahedron Asymmetry, 12 (8), 1151-1157 (2001)

Articles

Chromatographic enantiomeric separation of amino acids, like proline, is described for chiral GC analysis after derivatization.

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