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Merck
CN

67661

N-Nitrosoethylisopropylamine

analytical standard

Synonym(s):

N-Ethyl-N-nitroso-2-propanamine, EIPNA, NEIPA

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About This Item

Empirical Formula (Hill Notation):
C5H12N2O
CAS Number:
Molecular Weight:
116.16
MDL number:
UNSPSC Code:
12352116
NACRES:
NA.05
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Product Name

N-Nitrosoethylisopropylamine, analytical standard

SMILES string

N(N=O)(C(C)C)CC

InChI

1S/C5H12N2O/c1-4-7(6-8)5(2)3/h5H,4H2,1-3H3

InChI key

VGGZTNNNXAUZLB-UHFFFAOYSA-N

grade

analytical standard

assay

≥99%

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

storage temp.

2-8°C

Quality Level

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Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Application

N-Nitrosoethylisopropylamine may be used as an analytical reference standard for the determination of several nitrosamines in large volume parenteral (LVP) drug products using liquid chromatography-mass spectrometry (LC/MS/MS).

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N-Nitrosoethylisopropylamine is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.

pictograms

Health hazardExclamation mark

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

150.6 °F - (calculated)

flash_point_c

65.9 °C - (calculated)

Regulatory Information

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Development and Validation of a Sensitive LC-MS/MS Method for Simultaneous Determination of Several Nitrosamines in Large Volume Parenteral
Journal of AOAC (Association of Official Analytical Chemists) International, qsaf031-qsaf031 (2025)

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