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Merck
CN

442685

N-Nitrosodi-n-butylamine

analytical standard

Synonym(s):

N-Nitrosodibutylamine, Dibutyl nitrosamine, NDBA

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About This Item

Empirical Formula (Hill Notation):
C8H18N2O
CAS Number:
924-16-3
Molecular Weight:
158.24
UNSPSC Code:
12352200
PubChem Substance ID:
24867960
EC Number:
213-101-1
MDL number:
MFCD00013892
NACRES:
NA.24

Key Documents

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Product Name

N-Nitrosodi-n-butylamine, analytical standard

InChI key

YGJHZCLPZAZIHH-UHFFFAOYSA-N

InChI

1S/C8H18N2O/c1-3-5-7-10(9-11)8-6-4-2/h3-8H2,1-2H3

SMILES string

CCCCN(CCCC)N=O

grade

analytical standard

CofA

current certificate can be downloaded

packaging

ampule of 100 mg

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

density

0.9 g/mL (lit.)

application(s)

environmental

format

neat

storage temp.

2-30°C

Quality Level

100

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Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Application

N-Nitrosodi-n-butylamine solution may be used as an analytical reference standard for the quantification of low-molecular-weight N-nitrosamines in various pharmaceutical samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS).

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N-Nitrosodi-n-butylamine solution is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

hcodes

H302,H351

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
LRAD2881
LRAC8566
LRAC5148
LRAD7207
LC26905V

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Analysis of N-nitrosamines in water by isotope dilution gas chromatography -electron ionisation tandem mass spectrometry
McDonald JA, et al.
Talanta, 99, 146 -1154 (2012)
Determination of volatile nitrosamines in various meat products using comprehensive gas chromatography -nitrogen chemiluminescence detection
Ozel MZ, et al.
Food And Chemical Toxicology, 48(11), 3268 -33273 (2010)
A new method for quantifying N-nitrosamines in wastewater samples by gas chromatography?triple quadrupole mass spectrometry
Yoon S, et al.
Talanta, 97, 256 -2261 (2012)
A robust analytical method for simultaneous quantification of 13 low-molecular-weight N-Nitrosamines in various pharmaceuticals based on solid phase extraction and liquid chromatography coupled to high-resolution mass spectrometry
Parfant T, et al.
European Journal of Pharmaceutical Sciences, 192, 106633-106633 (2024)
N-nitrosodimethylamine (NDMA) removal by reverse osmosis and UV treatment and analysis via LC -MS/MS
Plumlee MH, et al.
Water Research, 42(1-2), 347 -3355 (2008)
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