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Astec® CYCLOBOND™ I 2000 AC Chiral (5 μm) HPLC Columns

L × I.D. 25 cm × 4.6 mm, HPLC Column

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Synonym(s):
Cyclodextrin-based Chiral Column
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52

product name

Astec® CYCLOBOND™ I 2000 AC Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm

material

stainless steel column

Quality Level

100

product line

Astec®

packaging

pkg of 1 ea

manufacturer/tradename

Astec®

parameter

0-50 °C temperature
172 bar pressure (2500 psi)

technique(s)

HPLC: suitable
LC/MS: suitable

L × I.D.

25 cm × 4.6 mm

matrix

silica particle platform

matrix active group

cyclodextrin, beta- phase

particle size

5 μm

pore size

100 Å

operating pH

3.5-7

separation technique

chiral

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General description

CYCLOBOND I 2000 AC is used primarily for aromatic alcohols or amines that are chiral on the α or β carbon.

  • Bonded phase: Acetylated beta-cyclodextrin

Resources:
CYCLOBOND FAQs
CYCLOBOND Reference Bibliography
Chiral Product Literature

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Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CYCLOBOND is a trademark of Sigma-Aldrich Co. LLC

Regulatory Information

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Separation of Beraprost sodium isomers using different cyclodextrin stationary phases
Walker, Thomas A.
Journal of Chromatography A, 633 (1-2), 97-103 (1993)
K H Kim et al.
Archives of pharmacal research, 23(3), 230-236 (2000-07-15)
(1'R, 2R)-, (1'R, 2S)-, (1'S, 2R)- and (1'S, 2S)-alpha-hydroxymetoprolol; (2R)- and (2S)-O-desmethylmetoprolol; and (2R)- and (2S)-metoprolol acid are major metabolites of (2R)-and (2S)-metoprolol, beta-adrenergic antagonist. The focus of most chiral separation methods until now has been on determination of the
Optical resolution of flavanones by high-performance liquid chromatography on various chiral stationary phases
Krause, Martin; Galensa, Rodolf
Journal of Chromatography A, 514, 147-159 (1990)
Reprint of: Enantiomeric separation of functionalized ethano-bridged Troger bases using macrocyclic cyclofructan and cyclodextrin chiral selectors in high-performance liquid chromatography and capillary electrophoresis with application of principal component analysis
Weatherly, Choyce A., et al.
Journal of Chromatography. B, Biomedical Applications, 968, 40-48 (2014)
Enantiomeric separation of functionalized ethano-bridged Troger bases using macrocyclic cyclofructan and cyclodextrin chiral selectors in high-performance liquid chromatography and capillary electrophoresis with application of principal component analysis
Weatherly, Choyce A., et al.
Journal of Chromatography. B, Biomedical Applications, 955-956, 72-80 (2014)
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Astec CYCLOBOND™

CYCLOBOND is the name given to Astec technology for bonding cyclodextrins to a high purity silica gel through a stable ether linkage.

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