Z0878
Zaprinast
cGMP-specific phosphodiesterases V and VI inhibitor, solid
Synonym(s):
1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one
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About This Item
Empirical Formula (Hill Notation):
C13H13N5O2
CAS Number:
Molecular Weight:
271.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
253-655-1
MDL number:
Form:
solid
Quality level:
Product Name
Zaprinast, solid
form
solid
Quality Level
color
white
solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL, DMSO: 10 mg/mL, H2O: insoluble
SMILES string
CCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2
InChI
1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
InChI key
REZGGXNDEMKIQB-UHFFFAOYSA-N
Gene Information
human ... PDE2A(5138), PDE4A(5141), PDE4B(5142), PDE4D(5144)
Application
Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect of it on the retinal cells by immunohistochemistry.
Biochem/physiol Actions
Zaprinast insubstantially inhibits phosphodiesterase 10 and 11 (PDE10 and PDE11). It also exhibits vasodilating effects.
Selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35
Taniguchi Y, et al.
Febs Letters, 580(21), 5003-5008 (2006)
A Sahaboglu et al.
Cell death & disease, 4, e488-e488 (2013-02-09)
For most neurodegenerative diseases the precise duration of an individual cell's death is unknown, which is an obstacle when counteractive measures are being considered. To address this, we used the rd1 mouse model for retinal neurodegeneration, characterized by phosphodiesterase-6 (PDE6)
Resumption of meiosis induced by meiosis-activating sterol has a different signal transduction pathway than spontaneous resumption of meiosis in denuded mouse oocytes cultured in vitro
Faerge I, et al.
Biology of Reproduction, 65(6), 1751-1758 (2001)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| Z0878-25MG | 04061832950082 |
| Z0878-100MG | 04061832950075 |