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Mivotilate; 2-(1,3-Dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-propanoic acid 1-methylethyl ester; Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl2-thiazol-2-yl)carbamoyl] acetate
C12H14N2O3S3
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Quality Level
Assay
≥98% (HPLC)
form
solid
solubility
DMSO: ≥5 mg/mL
storage temp.
2-8°C
SMILES string
CC(C)OC(=O)C(\C(=O)Nc1nc(C)cs1)=C2\SCS2
InChI
1S/C12H14N2O3S3/c1-6(2)17-10(16)8(11-19-5-20-11)9(15)14-12-13-7(3)4-18-12/h4,6H,5H2,1-3H3,(H,13,14,15)
InChI key
WOUUWUGULFOVHG-UHFFFAOYSA-N
Biochem/physiol Actions
YH439 is an aryl hydrocarbon receptor activator
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR.
Nucleic acids research, 39(9), 3695-3709 (2011-01-20)
The basic helix-loop-helix (bHLH).PAS dimeric transcription factors have crucial roles in development, stress response, oxygen homeostasis and neurogenesis. Their target gene specificity depends in part on partner protein choices, where dimerization with common partner Aryl hydrocarbon receptor nuclear translocator (Arnt)
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