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Merck
CN

Y1521

YS-49 monohydrate

≥98% (HPLC)

Synonym(s):

1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate

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About This Item

Empirical Formula (Hill Notation):
C20H19NO2 · HBr · H2O
CAS Number:
132836-42-1
Molecular Weight:
404.30
NACRES:
NA.77
PubChem Substance ID:
329831588
UNSPSC Code:
12352200
MDL number:
MFCD16875442

Key Documents

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Product Name

YS-49 monohydrate, ≥98% (HPLC)

InChI

1S/C20H19NO2.BrH.H2O/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14;;/h1-7,11-12,18,21-23H,8-10H2;1H;1H2

SMILES string

O.Br.Oc1cc2CCNC(Cc3cccc4ccccc34)c2cc1O

InChI key

QHCUNMLYODPTIU-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

YS-49 protects cells from oxidant injury; anti-inflammatory agent; activator of PI3K/Akt signaling. YS-49, an analog of higenamine, induces heme oxygenase (HO-1) in endothelial cells and protects cells from oxidant injury. The compound was reported to inhibit Ang II-stimulated VSMC proliferation through HO-1 production, which inhibits both the JNK pathway and ROS production. A study (JPET) reported that CKD712 (S-YS-49) confer cardiac protection and anti-inflammatory via activation of the PI3K signal pathway. These effects were antagonized by a PI3K inhibitor, wortmannin.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
020M4618V
020M4618

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