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X6000

Sigma-Aldrich

Xylometazoline hydrochloride

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Synonym(s):
2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline hydrochloride
Empirical Formula (Hill Notation):
C16H24N2 · HCl
CAS Number:
1218-35-5
Molecular Weight:
280.84
EC Number:
214-936-4
MDL number:
MFCD00238707
UNSPSC Code:
12352200
PubChem Substance ID:
24278781
NACRES:
NA.77

Quality Level

200

originator

Novartis

SMILES string

CC1=CC(C(C)(C)C)=CC(C)=C1CC2=NCCN2.Cl

InChI

1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H

InChI key

YGWFCQYETHJKNX-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Related Categories

Biochem/physiol Actions

α-adrenoceptor agonist; imidazoline binding site ligand.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Görkem Eskiizmir et al.
European journal of clinical pharmacology, 67(1), 19-23 (2010-11-12)
Oxymetazoline and xylometazoline are locally effective and direct acting drugs that relieve nasal congestion. The aim of this study was to objectively determine and compare the decongestive effects of oxymetazoline and xylometazoline in healthy subjects. The study population comprised thirty
Britta Haenisch et al.
Fundamental & clinical pharmacology, 24(6), 729-739 (2009-12-25)
Oxymetazoline and xylometazoline are both used as nasal mucosa decongesting α-adrenoceptor agonists during a common cold. However, it is largely unknown which of the six α-adrenoceptor subtypes are actually present in human nasal mucosa, which are activated by the two
I T Bognar et al.
The Journal of pharmacology and experimental therapeutics, 254(2), 702-710 (1990-08-01)
Rat hearts were isolated with the vagus nerves intact and perfused, and the neuronal acetylcholine stores were pulse labeled with [14C]choline. The overflow of [14C]choline/acetylcholine evoked by extrinsic vagus nerve stimulation (3 Hz and 720 pulses or 10 Hz and
Helle L Thulesius et al.
Rhinology, 49(1), 46-52 (2011-04-07)
Rhinomanometry before and after decongestion distinguishes a nasal airway organic stenosis from congestion of nasal mucosa in patients with nasal stuffiness. Together with rhinoscopy and patient history, it is used to decide if nasal surgery would benefit the patient. Rhinomanometry
Daniela Leupold et al.
The neurologist, 17(1), 41-43 (2010-12-31)
substance abuse is an important cause of ischemic stroke in the young. This includes over-the-counter dietary supplements and cough and cold remedies, which were reported to be an independent risk factor for hemorrhagic stroke. this article describes a young male
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