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Merck
CN

X2754

Xanomeline L-tartrate hydrate

≥98% (HPLC)

Synonym(s):

3-Hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole, LY-246708, Lomeron, Memcor

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About This Item

Empirical Formula (Hill Notation):
C14H23N3OS · xC4H6O6 · yH2O
Molecular Weight:
281.42 (anhydrous free base basis)
NACRES:
NA.77
PubChem Substance ID:
329830801
UNSPSC Code:
12352200
MDL number:
MFCD16879016

Key Documents

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Product Name

Xanomeline L-tartrate hydrate, ≥98% (HPLC)

form

powder

InChI key

YTWKANAWFZNIKV-UACZKNEHSA-N

SMILES string

O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCCCCCOc1nsnc1C2=CCCN(C)C2

InChI

1S/C14H23N3OS.C4H6O6.H2O/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12;5-1(3(7)8)2(6)4(9)10;/h8H,3-7,9-11H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10);1H2/t;1-,2-;/m.1./s1

assay

≥98% (HPLC)

storage condition

desiccated
under inert gas

color

off-white

solubility

H2O: 10 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Xanomeline L-tartate is a M1 muscarinic receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
124M4607V
093M4620V
111M4621V
099K46071
099K4607

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Kristine B Jørgensen et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 202(1), 7-15 (2015-11-02)
The present study investigated the cholinergic system in the African naked mole-rat (Heterocephalus glaber) with focus on the muscarinic acetylcholine receptor subtypes M1 and M4. The protein sequences for the subtypes m 1-5 of the naked mole-rat were compared to
Karin Hellman et al.
ACS chemical neuroscience, 11(2), 173-183 (2019-12-19)
Current antipsychotic drugs are notably ineffective at addressing the cognitive deficits associated with schizophrenia. N-Desmethylclozapine (NDMC), the major metabolite of clozapine, displays muscarinic M1 receptor (M1) agonism, an activity associated with improvement in cognitive functioning. Preclinical and clinical data support

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