X2628
Xestospongin C
IP3 receptor Inhibitor, film
Synonym(s):
XeC
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Linear Formula:
C28 H50 N2 O2
CAS Number:
Molecular Weight:
446.71
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Xestospongin C, film
SMILES string
[H][C@@]12CCCCCC[C@@]3([H])CCCN4CC[C@@]([H])(CCCCCC[C@]5([H])CCCN(CC1)[C@@]5([H])O2)O[C@@]34[H]
InChI
1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m1/s1
InChI key
PQYOPBRFUUEHRC-HCKQMYSWSA-N
form
film
color
colorless
solubility
DMSO: soluble
shipped in
dry ice
storage temp.
−20°C
Quality Level
Related Categories
Biochem/physiol Actions
Xestospongin C is a potent, reversible and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50=358 nM).
Xestospongin C is a selective, reversible and membrane-permeable inhibitor of IP3 receptor. Reversibly blocks bradykinin- and carbamylcholine- Ca2+ efflux from the endoplasmic reticulum stores.
Features and Benefits
This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge.
Packaging
Package under nitrogen, tightly sealed.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Shaily Malik et al.
Frontiers in molecular neuroscience, 10, 404-404 (2017-12-21)
Human immunodeficiency virus-1 (HIV-1) infection compromises the central nervous system (CNS) in a significant number of infected individuals, resulting in neurological dysfunction that ranges from minor cognitive deficits to frank dementia. While macrophages/microglia are the predominant CNS cells infected by
Andrei V Chernov et al.
The Journal of biological chemistry, 295(31), 10807-10821 (2020-06-14)
In the peripheral nerve, mechanosensitive axons are insulated by myelin, a multilamellar membrane formed by Schwann cells. Here, we offer first evidence that a myelin degradation product induces mechanical hypersensitivity and global transcriptomics changes in a sex-specific manner. Focusing on
Martin Prince Alphonse et al.
Journal of immunology (Baltimore, Md. : 1950), 197(9), 3481-3489 (2016-10-04)
Kawasaki disease (KD) is a multisystem vasculitis that predominantly targets the coronary arteries in children. Phenotypic similarities between KD and recurrent fever syndromes point to the potential role of inflammasome activation in KD. Mutations in NLRP3 are associated with recurrent
Hirofumi Morihara et al.
PloS one, 12(12), e0189948-e0189948 (2017-12-22)
Excessive levels of reactive oxygen species (ROS) and impaired Ca2+ homeostasis play central roles in the development of multiple cardiac pathologies, including cell death during ischemia-reperfusion (I/R) injury. In several organs, treatment with 2-aminoethoxydiphenyl borate (2-APB) was shown to have
S Miyamoto et al.
British journal of pharmacology, 130(3), 650-654 (2000-05-24)
We evaluated the role of the inositol 1,4,5-triphosphate (IP(3)) receptor-mediated Ca(2+) release on the positive inotropic effects of alpha-adrenergic stimulation using a novel, potent, selective membrane-permeable blocker of IP(3) receptor, xestospongin C. Guinea-pig papillary muscle permeabilized with saponin exhibited spontaneous
Related Content
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service