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WH0004041M1

Sigma-Aldrich

Monoclonal Anti-LRP5 antibody produced in mouse

clone 1E9, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-BMND1, Anti-HBM, Anti-LR3, Anti-LRP7, Anti-OPPG, Anti-OPS, Anti-VBCH2, Anti-low density lipoprotein receptor-related protein 5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1E9, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

NM_002335

UniProt accession no.

O75197

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LRP5(4041)

Related Categories

General description

Low-density lipoprotein receptor-related protein 5 or LRP5 functions as a co-receptor for the Wnt signaling complex. LRP5 is involved in various processes such as bone mass regulation, pulmonary angiogenesis, and alveolar synthesis . Monoclonal Anti-LRP5 antibody is specific for LRP5 in humans.

Immunogen

LRP5 (NP_002326.1, 41 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
RDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETN

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

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Tadanori Mammoto et al.
PloS one, 7(7), e41596-e41596 (2012-08-01)
Angiogenesis is crucial for lung development. Although there has been considerable exploration, the mechanism by which lung vascular and alveolar formation is controlled is still not completely understood. Here we show that low-density lipoprotein receptor-related protein 5 (LRP5), a component
Yajun Cui et al.
Nature medicine, 17(6), 684-691 (2011-05-24)
The human skeleton is affected by mutations in low-density lipoprotein receptor-related protein 5 (LRP5). To understand how LRP5 influences bone properties, we generated mice with osteocyte-specific expression of inducible Lrp5 mutations that cause high and low bone mass phenotypes in

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