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Merck
CN

V9889

Valacyclovir hydrochloride hydrate

≥98% (HPLC), solid

Synonym(s):

2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester monohydrochloride, L-Valine, Valtrex

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About This Item

Empirical Formula (Hill Notation):
C13H20N6O4 · HCl · xH2O
CAS Number:
124832-27-5
Molecular Weight:
360.80 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329830241
NACRES:
NA.32

Key Documents

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SMILES string

O.Cl.CC(C)[C@H](N)C(=O)OCCOCn1cnc2C(=O)NC(N)=Nc12

InChI

1S/C13H20N6O4.ClH.H2O/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20;;/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20);1H;1H2/t8-;;/m0../s1

InChI key

KNOVZDRKHSHEQN-JZGIKJSDSA-N

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: >20 mg/mL

antibiotic activity spectrum

viruses

mode of action

DNA synthesis | interferes

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

Valacyclovir hydrochloride hydrate is a potent inhibitor of viral DNA polymerase.
Valacyclovir hydrochloride hydrate is potent inhibitor of viral DNA polymerase. It is a prodrug of acyclovir that is useful in viral, AIDS, and immune system regulation research.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000244923
070M4726V
0000244923
0000174957
0000174957

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S P Alexopoulos et al.
Current medicinal chemistry, 19(35), 5957-5963 (2012-09-12)
Human Cytomegalovirus is a commonly identified herpesvirus that establishes a state of latent infection in the majority of the population by adulthood. A coordinated immune response involving both the innate and adaptive immune system prevents active viral replication and disease.
Leigh Zerboni et al.
Journal of virology, 87(5), 2791-2802 (2012-12-28)
The tropism of herpes simplex virus (HSV-1) for human sensory neurons infected in vivo was examined using dorsal root ganglion (DRG) xenografts maintained in mice with severe combined immunodeficiency (SCID). In contrast to the HSV-1 lytic infectious cycle in vitro
Shin-ichi Sasaki et al.
The British journal of ophthalmology, 97(4), 498-503 (2013-01-31)
To determine the efficacy of a new helicase-primase inhibitor, ASP2151, for treating herpetic keratitis. Murine corneas were infected with herpes simplex virus type 1 (HSV-1). ASP2151 was administered orally or topically, and the severity of epithelial dendritic keratitis was determined.
Mark Beswick et al.
Journal of virology, 87(2), 779-789 (2012-11-02)
Cytomegalovirus (CMV) infection leads to the development of adaptive and humoral immune responses that are among the largest for any pathogen, and intriguingly, the magnitude of the immune response increases with age, a phenomenon termed "memory inflation." Elevated CMV-specific immunity
Maine Trece de Siqueira Santos do Amaral et al.
Aesthetic surgery journal, 39(4), NP68-NP75 (2018-09-12)
Rhinophyma results in nasal deformity, which may lead to significant distress, embarrassment, social isolation, and low self-esteem. Fractional carbon dioxide (CO2) laser treatment is a simple, noninvasive, outpatient procedure with a low complication rate that has proved useful in rhinophyma
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