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V2514

Sigma-Aldrich

Anti-VGLUT2 (HY-19) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-DNPI, Anti-VGLUT2

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About This Item

MDL number:
MFCD05865393
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 65 kDa

species reactivity

rat

technique(s)

western blot: 1:2,000 using synaptic vesicle (SV) fraction of rat brain

UniProt accession no.

Q9JI12

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC17A6(57084)
mouse ... Slc17a6(140919)
rat ... Slc17a6(84487)

Related Categories

General description

Vesicular glutamate transporter 2 (vGluT2), also known as solute carrier family 17 member 6 (SLC17A6), is encoded by the gene mapped to human chromosome 11p14.3. The encoded protein belongs to the SLC17 family of transporters. vGluT2 is an integral membrane protein with 12 predicted transmembrane domains. It is localized on synaptic vesicles and is expressed mainly in neurons and endocrine terminals.

Immunogen

synthetic peptide located near the C-terminus of rat VGLUT2 (amino acids 520-538). The sequence is identical in mouse and human VGLUT2 and has no homology to VGLUT1.

Application

Anti-VGLUT2 (HY-19) antibody produced in rabbit has been used in:
  • western blot
  • immunolabelling.
  • immunohistochemistry.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem/physiol Actions

Vesicular glutamate transporters (vGluT) play a vital role in the transport of glutamate into secretory vesicles. They are also used as a specific markers to recognize glutamatergic neurons. vGluT2 is considered to be a potent target for reducing glutamatergic neurotransmission. Thus, vGluT2 could be useful for the treatment of neurodegenerative diseases in which chronic excessive glutamate signaling has been involved. It is also used for treating epilepsy and pain.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Growth and refinement of excitatory synapses in the human auditory cortex.
.Pundir A S, et al.
Brain Structure &Amp; Function, 221(7), 3641-3674 (2016)
Expression of vesicular glutamate transporter 2 (vGluT2) on large dense-core vesicles within GnRH neuroterminals of aging female rats.
Yin W, et al.
PLoS ONE, 10(6), e0129633-e0129633 (2015)
Intracortical excitatory and thalamocortical boutons are intact in primary auditory cortex in schizophrenia.
Moyer C E, et al.
Schizophrenia Research, 149(1), 127-134 (2013)
Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres.
Virolainen S-M, et al.
Development, 139(20), 3795-3805 (2012)
SLC17: a functionally diverse family of organic anion transporters.
Reimer R J.
Molecular Aspects of Medicine, 350-359, 34(2-343) (2013)
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