V108
(±)-Norverapamil hydrochloride
≥98% (HPLC)
Synonym(s):
N-Nor-(±)-verapamil hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C26H36N2O4 · HCl
CAS Number:
Molecular Weight:
477.04
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 15 mg/mL, clear
SMILES string
CC(C)C(CCCNCCC1=CC=C(OC)C(OC)=C1)(C#N)C2=CC(OC)=C(OC)C=C2.Cl
InChI
1S/C26H36N2O4.ClH/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5;/h8-11,16-17,19,28H,7,12-15H2,1-6H3;1H
InChI key
OEAFTRIDBHSJDC-UHFFFAOYSA-N
Biochem/physiol Actions
Norverapamil is an N-demethylated metabolite of verapamil. It has significantly less calcium channel blocking ability and exhibit therapeutic activity.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Stereoselective determination of verapamil and norverapamil by capillary electrophoresis
Dethy J M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 654(1), 121-127 (1994)
Yong-Ji Piao et al.
Archives of pharmacal research, 31(4), 518-522 (2008-05-02)
The aim of this study was to investigate the effects of hesperidin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rats. The pharmacokinetic parameters of verapamil and norverapamil in rats were measured after the oral administration of
Simultaneous determination of verapamil and norverapamil in biological samples by high-performance liquid chromatography using ultraviolet detection
Garcia M A, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 693(2), 377-382 (1997)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| V108-5MG | 04061832964317 |