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UC448

Sigma-Aldrich

Paracetamol sulfate potassium salt

solid, ≥97% (HPLC)

Synonym(s):

4-Acetamidophenol sulfate ester potassium salt, Acetaminophen sulfate potassium salt, N-(4-Sulfoxyphenyl)acetamide monopotassium salt

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About This Item

Empirical Formula (Hill Notation):
C8H8KNO5S
CAS Number:
32113-41-0
Molecular Weight:
269.32
MDL number:
MFCD01631667
UNSPSC Code:
12161501
PubChem Substance ID:
329827671
NACRES:
NA.77
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Quality Level

200

Assay

≥97% (HPLC)

form

solid

color

white to off-white

mp

163 °C

solubility

H2O: soluble

storage temp.

2-8°C

SMILES string

[K+].CC(=O)Nc1ccc(OS([O-])(=O)=O)cc1

InChI

1S/C8H9NO5S.K/c1-6(10)9-7-2-4-8(5-3-7)14-15(11,12)13;/h2-5H,1H3,(H,9,10)(H,11,12,13);/q;+1/p-1

InChI key

AJYPYWFCUWHZMZ-UHFFFAOYSA-M

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1-萘酚-3,6-二磺酸 二钠盐 水合物 technical grade

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甘氨酸 钠盐 水合物 98%

219517

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form

solid

form

powder

form

-

form

solid

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

grade

p.a.

grade

-

grade

-

grade

-

technique(s)

UV/Vis spectroscopy: suitable

technique(s)

-

technique(s)

-

technique(s)

-

General description

Paracetamol is an aminophenol derivative. It functions as an analgesic and antipyretic drug, which has weak inflammatory effect. Paracetamol is used to treat pyrexia and mild to moderate pain.[1] It might inhibit atherosclerosis through its antioxidant activity.[2]

Application

Paracetamol sulfate potassium salt has been used as a standard for HPLC assays of acetaminophen[3].

Biochem/physiol Actions

Phase II metabolite of paracetamol.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Paracetamol sulfate potassium salt is soluble in water.

Other Notes

Occasionally, it may be necessary to supply as the sodium salt

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H315,H317,H318,H335

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000361592
0000361591
0000191746
0000191757
0000165770

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Hayati Filik et al.
Chemical & pharmaceutical bulletin, 54(6), 891-896 (2006-06-07)
In the present paper, conventional spectrophotometry in conjunction with cloud point extraction-preconcentration were investigated as alternative methods for paracetamol (PCT) assay in urine samples. Cloud point extraction (CPE) was employed for the preconcentration of p-aminophenol (PAP) prior to spectrophotometric determination
A Alberti et al.
Biological psychiatry, 46(3), 420-424 (1999-08-06)
Parents of autistic children and autism support groups often report that autistic episodes are exacerbated when the children eat certain foodstuffs such as dairy products, chocolates, wheat, corn sugar, apples, and bananas. The hypothesis that autistic behavior might be related
L S Jensen et al.
Journal of pharmaceutical and biomedical analysis, 34(3), 585-593 (2004-05-07)
A range of analytical methods exist for the determination of paracetamol in biological fluids. However, to understand the fate of paracetamol and the effect of other drugs on its disposition in vivo, the major metabolites require quantification in urine and
Maciej J Zamek-Gliszczynski et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(8), 1158-1165 (2005-04-30)
Previous reports have demonstrated that sulfate metabolites may be excreted into bile by the multidrug resistance-associated protein 2 (Mrp2, Abcc2). Although recombinant human breast cancer resistance protein (BCRP, ABCG2) has affinity for sulfated xenobiotics and endobiotics, its relative importance in
H Xiong et al.
The Journal of pharmacology and experimental therapeutics, 295(2), 512-518 (2000-10-25)
Previous studies have demonstrated that phenobarbital treatment impairs the biliary excretion of acetaminophen glucuronide (AG), although the transport system(s) responsible for AG excretion into bile has not been identified. Initial studies in rat canalicular liver plasma membrane vesicles indicated that
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