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Merck
CN

UC261

(±)-4-Hydroxydebrisoquin sulfate

Synonym(s):

(±)-2-Amidino-4-hydroxy-1,2,3,4-tetrahydroisoquinoline sulfate, (±)-3,4-Dihydro-4-hydroxy-2(1H)-isoquinolinecarboximidamide sulfate

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About This Item

Empirical Formula (Hill Notation):
C10H13N3O · 0.5H2SO4
CAS Number:
62580-84-1
Molecular Weight:
240.27
NACRES:
NA.77
PubChem Substance ID:
329827663
UNSPSC Code:
12161501
MDL number:
MFCD09840718

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InChI

1S/2C10H13N3O.H2O4S/c2*11-10(12)13-5-7-3-1-2-4-8(7)9(14)6-13;1-5(2,3)4/h2*1-4,9,14H,5-6H2,(H3,11,12);(H2,1,2,3,4)

SMILES string

OS(O)(=O)=O.NC(=N)N1CC(O)c2ccccc2C1.NC(=N)N3CC(O)c4ccccc4C3

InChI key

AETJLQVZNVTWPH-UHFFFAOYSA-N

form

solid

color

off-white

mp

267 °C

storage temp.

2-8°C

Quality Level

200

Related Categories

Application

(±)-4-Hydroxydebrisoquin sulfate can be used for the metabolic studies of debrisoquin.

Biochem/physiol Actions

CYP2D6 metabolite of debrisoquin.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000108069
0000021005
BGBC3617V
1385690
036K3252

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R Ismail et al.
Journal of clinical pharmacy and therapeutics, 25(5), 379-383 (2000-12-21)
Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of
Determination of oxidation phenotype by measurement of propafenone urinary metabolic ratios.
P Lledó et al.
Human & experimental toxicology, 12(2), 161-163 (1993-03-01)
M J Steiger et al.
Acta neurologica Scandinavica, 86(2), 159-164 (1992-08-01)
Debrisoquine (DBQ) metabolism was studied in 80 Parkinson's disease (PD) patients, 26 of whom had young onset Parkinson's disease (YOPD), and in 143 controls. There was no significant difference between the proportion of poor metabolisers of DBQ among YOPD patients
Miki Katoh et al.
Journal of pharmaceutical sciences, 96(2), 428-437 (2006-10-20)
We previously clarified that major human drug metabolizing enzymes were expressed in a chimeric urokinase-type plasminogen activator (uPA)+/+/severe combined immunodeficient (SCID) mouse line established recently, in which the liver could be replaced by more than 80% with human hepatocytes. In
A Bozkurt et al.
Journal of pharmaceutical and biomedical analysis, 11(8), 745-749 (1993-08-01)
A simple, selective and sensitive method has been developed to determine debrisoquine and 4-hydroxydebrisoquine in human urine. Separation of the analytes was obtained using a mobile phase of 0.1 M sodium dihydrogen phosphate-acetonitrile (87:13, v/v) and a muBondapak C18 column.
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