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U8008

Sigma-Aldrich

Anti-ULK2 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Ulk2 Antibody, Ulk2 Antibody - Anti-ULK2 antibody produced in rabbit, Anti-Unc-51 like kinase 2, Anti-Unc51.2
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~130 kDa

species reactivity

mouse

concentration

~1.0 mg/mL

technique(s)

western blot: 2.5-5.0 μg/mL using whole extracts of HEK-293T cells expressing mouse ULK2

UniProt accession no.

Q9QY01

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ULK2(9706)
mouse ... Ulk2(29869)
rat ... Ulk2(303206)

General description

Uncoordinated family member (unc)-51 like autophagy activating kinase 2 (ULK2) is encoded by the gene mapped to mouse chromosome 11. Mouse ULK2 (mULK2) belongs to the UNC-51-like protein kinase family. mULK2 protein is characterized with an amino-terminal kinase domain, a central proline/serine rich (PS) domain and a carboxy-terminal (C) domain. ULK2 is ubiquitously expressed and is mainly localized to autophagosomal membranes in mammalian cells.

Application

Anti-ULK2 antibody produced in rabbit has been used in western blot analysis and immunohistochemistry.

Biochem/physiol Actions

Uncoordinated family member (unc)-51 like autophagy activating kinase 2 (ULK2) plays a crucial role in autophagy. It is also implicated in the regulation of elemental biological processes conserved among wide variety of species. Downregulated expression of the gene increases astrocyte transformation and tumor growth.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy
Lee EJ and Tournier C
Autophagy, 7, 689-695 (2011)
Ammonia-induced autophagy is independent of ULK1/ULK2 kinases.
Cheong H
Proceedings of the National Academy of Sciences of the USA, 108, 11121-11126 (2011)
Methylation Silencing of ULK2, an Autophagy Gene, Is Essential for Astrocyte Transformation and Tumor Growth
Shukla S
The Journal of Biological Chemistry, 289, 22306-22318 (2014)
Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse
Bi W
Genome Research, 12, 713-728 (2002)
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
Nazio F
Nature Cell Biology, 15, 406-416 (2013)
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