U2875
Uric acid sodium salt
Synonym(s):
2,6,8-Trihydroxypurine, Sodium acid urate
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About This Item
Linear Formula:
C5H3N4O3Na
CAS Number:
Molecular Weight:
190.09
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
214-838-1
MDL number:
InChI key
IHMJZGFANDMEJM-UHFFFAOYSA-N
InChI
1S/C5H4N4O3.Na.H/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;;/h(H4,6,7,8,9,10,11,12);;
SMILES string
[Na].O=C1NC(=O)C2=C(N1)NC(=O)N2
biological source
microbial
synthetic
assay
11.0-13.0% anhydrous basis (Sodium, ICP)
form
powder
solubility
1 M NaOH: 25 mg/mL, clear, colorless to faintly yellow
Quality Level
Related Categories
Application
Uric acid sodium salt has been used in isotonic solution of NaCl dose titration study. It has been used as a suspension in NaCl for intra-articular administration to experimental animals to induce synovitis.
Biochem/physiol Actions
Sodium urate is the sodium salt of uric acid. In gout, it is observed in synovial fluid. Sodium urate has been shown to precipitate calcium oxalate from urine. It is also known to reverse the inhibitory effects of reactive oxygen and nitrogen metabolites on gelatinase A activity. Excess sodium urate in soft tissues results in a condition referred to as tophi.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A pharmacokinetic/pharmacodynamic approach vs. a dose titration for the determination of a dosage regimen: the case of nimesulide, a Cox-2 selective nonsteroidal anti-inflammatory drug in the dog
Toutain PL, et al.
Journal of Veterinary Pharmacology and Therapeutics, 24(1), 43-55 (2001)
Effects of reactive metabolites of oxygen and nitrogen on gelatinase A activity
Owens MW, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 273(2), L445-L450 (1997)
Bin Zhang et al.
Cellular and molecular neurobiology, 37(5), 931-939 (2016-10-07)
Cerebral infarction (CI) is a common clinical cerebrovascular disease, and to explore the pathophysiological mechanisms and seek effective treatment means are the hotspot and difficult point in medical research nowadays. Numerous studies have confirmed that uric acid plays an important
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Journal of natural medicines, 75(1), 37-47 (2020-08-08)
Monosodium urate (MSU)-mediated inflammation is closely related to gouty arthritis (GA). Dioscin, an active ingredient, has been reported to possess anti-inflammatory property. Nevertheless, the role of dioscin in GA and the underlying mechanism have not been fully understood. In the
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