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U1006

Sigma-Aldrich

Uridine 5′-triphosphate trisodium salt solution

HPLC purified, aqueous solution for RNA polymerase transcription

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Synonym(s):
UTP
MDL number:
MFCD00044310
UNSPSC Code:
41106305
PubChem Substance ID:
24900622
NACRES:
NA.52

biological source

yeast (Candida Utilis)

Quality Level

300

Assay

≥95 (HPLC)

form

liquid

concentration

100 mM in H2O (adjusted to pH 7 with Trizma®
base)

color

colorless

foreign activity

DNase and RNase, none detected

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI

1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1

InChI key

MMJGIWFJVDOPJF-LLWADOMFSA-K

Gene Information

human ... P2RY2(5029)
rat ... P2ry2(29597)

Related Categories

Application

Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca2+ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).

Biochem/physiol Actions

UTP plays a crucial role in the process of transcription by participating in the synthesis of RNA. It is associated with glycogen synthesis, protein glycosylation, and membrane phospholipid biosynthesis. UTP is involved in the production of ATP, which is essential for metabolic reactions.
Uridine 5′-triphosphate (UTP) is released during nerve injury and acts as an agonist of the purinergic P2Y2 receptors present on the surface of Schwann cells.

Legal Information

Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Aloa Lamarca et al.
PloS one, 9(6), e98998-e98998 (2014-06-07)
In response to peripheral nerve injury, Schwann cells adopt a migratory phenotype and modify the extracellular matrix to make it permissive for cell migration and axonal re-growth. Uridine 5'-triphosphate (UTP) and other nucleotides are released during nerve injury and activate
Uridine metabolism and its role in glucose, lipid, and amino acid homeostasis
Zhang Y, et al.
BioMed Research International, 2020 (2020)
Biochemistry of uridine in plasma
Yamamoto T, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 412(19-20), 1712-1724 (2011)
Ann-Sofie Jemth et al.
Nucleic acids research, 46(20), 10888-10904 (2018-10-12)
Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides like O6-methyl-dGTP can be mutagenic and toxic if incorporated into DNA. Removal of methylated nucleotides from the nucleotide pool
Anne Hahn et al.
Physiological reports, 5(12) (2017-06-24)
Transport of water and electrolytes in airway epithelia involves chloride-selective ion channels, which are controlled either by cytosolic Ca2+ or by cAMP The contributions of the two pathways to chloride transport differ among vertebrate species. Because rats are becoming more

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