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T9951

Sigma-Aldrich

Monoclonal Anti-Tyrosinase antibody produced in mouse

clone T311, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-OCA1A, Anti-OCAIA, Anti-Tyrosinase (oculocutaneous albinism IA)

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About This Item

MDL number:
MFCD01322752
UNSPSC Code:
12352203

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

T311, monoclonal

form

buffered aqueous solution

mol wt

antigen ~70 kDa

species reactivity

human

technique(s)

immunocytochemistry: suitable
immunohistochemistry : suitable
indirect ELISA: suitable
western blot: 1-2 μg/mL using total cell extract of SKMEL19 cells

isotype

IgG2a

UniProt accession no.

P14679

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TYR(7299)

Immunogen

recombinant human tyrosinase protein.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
037K4811

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Elisa Greggio et al.
Journal of neurochemistry, 93(1), 246-256 (2005-03-19)
Tyrosinase is a key enzyme in the synthesis of melanin in skin and hair and has also been proposed to contribute to the formation of neuromelanin (NM). The presence of NM, which is biochemically similar to melanin in peripheral tissues
K S Clarkson et al.
Journal of clinical pathology, 54(3), 196-200 (2001-03-17)
To compare the sensitivity and staining pattern of the new immunohistochemical antibody to tyrosinase (T311) with S-100, HMB45, and the recently evaluated antibody to melan-A (A103) in a range of melanocytic lesions. Archival, formalin fixed, paraffin wax embedded sections from
Y T Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(18), 8125-8129 (1995-08-29)
Tyrosinase (EC 1.14.18.1), the key enzyme in melanin synthesis, has been shown to be one of the targets for cytotoxic T-cell recognition in melanoma patients. To develop serological reagents useful for immunophenotyping melanoma for tyrosinase, human tyrosinase cDNA was expressed
A A Jungbluth et al.
Pathology, research and practice, 196(4), 235-242 (2000-04-27)
Tyrosinase is a key enzyme in melanin biosynthesis and represents a marker of melanocytic differentiation. We previously generated T311, a murine monoclonal antibody to the tyrosinase recombinant protein. This study was performed to evaluate T311 as a diagnostic immunohistochemical reagent
Dake Dong et al.
Lasers in medical science, 29(5), 1649-1654 (2014-04-09)
Both high-intensity ultraviolet and narrowband ultraviolet B (NB-UVB) are important therapeutic options for vitiligo management, but high-intensity ultraviolet is more effective than NB-UVB. However, the underlying mechanisms have not been well investigated. Herein, we compare the effects of high-intensity ultraviolet
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