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T9924

Sigma-Aldrich

Troponin I from human heart

lyophilized powder

Synonym(s):

Tn-I

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About This Item

CAS Number:
77108-40-8
MDL number:
MFCD00213059
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human heart

Quality Level

200

form

lyophilized powder

purified by

affinity chromatography

technique(s)

inhibition assay: suitable

solubility

water: 5 vial/mL, clear, colorless

UniProt accession no.

P19429

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TNNI3(7137)

Application

Troponin I from human heart can be used in studies whether the actin and aldolase can protect rabbit muscle lactate dehydrogenase inhibition by ascorbate or not.

Biochem/physiol Actions

The inhibiting subunit of troponin, responsible for preventing actin-myosin binding and ATPase activity.
Troponin I interacts with tropomyosin for regulating the contraction of striated muscle in a calcium-dependent manner. Additionally, Troponin I can also inhibits actomyosin ATPase and serves as a selective and potent inhibitor of angiogenesis in vivo and in vitro and of tumor metastasis in vivo.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Nikita Sitkov et al.
Micromachines, 12(6) (2021-07-03)
The problems of chronic or noncommunicable diseases (NCD) that now kill around 40 million people each year require multiparametric combinatorial diagnostics for the selection of effective treatment tactics. This could be implemented using the biosensor principle based on peptide aptamers
Percy J Russell et al.
Journal of enzyme inhibition and medicinal chemistry, 19(1), 91-98 (2004-06-19)
Muscle-type LDH (LDH-m4) activity is critical for efficient anaerobic glycolysis. The results here show that rabbit LDH-M4 is inhibited by concentrations of ascorbate normally found in tissues. Aldolase and muscle G-actin were found to protect and to reverse inhibitions of
M A Moses et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(6), 2645-2650 (1999-03-17)
Cartilage is an avascular and relatively tumor-resistant tissue. Work from a number of laboratories, including our own, has demonstrated that cartilage is an enriched source of endogenous inhibitors of angiogenesis. In the course of a study designed to identify novel

Articles

Troponin

Troponin together with tropomyosin, regulate the binding of myosin to actin. Troponin is a trimeric protein composed of Troponin subunits I, C and T. Troponin C binds calcium ions, Troponin T binds to tropomyosin and troponin I binds to actin

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