T9145
Thyroglobulin from bovine thyroid
(For Gel Filtration Chromatography)
Synonym(s):
Tg
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About This Item
biological source
bovine thyroid
Quality Level
form
powder
mol wt
~670 kDa
technique(s)
bioconjugation: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... TG(280706)
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Application
Thyroglobulin is used for antibody purification and characterization. Thyroglobulin has been used in studies assessing the monitoring of differentiated thyroid cancer as well as to develop an accurate diagnostic tool for patients with autoimmune thyroid diseases.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Biochem/physiol Actions
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Morgan E Abernathy et al.
NPJ vaccines, 6(1), 126-126 (2021-10-27)
HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses to off-target regions of HIV-1 Env. We report characterization of Ab1245, an off-target antibody against the Env gp120-gp41 interface, from
Perrine Munier et al.
Annales de biologie clinique, 69(6), 721-725 (2011-11-30)
Thyroglobuline (Tg) is a large molecule of high molecular weight mainly indicated in monitoring differentiated thyroid cancer (DTC), its measurement remains difficult. We report the case of a patient who underwent total thyroidectomy for a poorly differentiated thyroid insular carcinoma.
Andrew N Hoofnagle et al.
Clinical chemistry, 54(11), 1796-1804 (2008-09-20)
Quantification of serum tumor markers plays an important role in determining whether patients treated for cancer require further therapy. Whereas large-scale proteomic efforts aim to identify novel tumor markers to facilitate early detection, optimization of methods for quantifying known tumor
Akio Yoshida et al.
The Journal of clinical endocrinology and metabolism, 94(2), 442-448 (2008-12-04)
Pendrin is an apical protein of thyroid follicular cells, responsible for the efflux of iodide into the follicular lumen via an iodide-chloride transport mechanism. It is unknown whether pendrin is recognized by autoantibodies. Our objective was to examine the prevalence
Kookjoo Kim et al.
Acta crystallographica. Section D, Structural biology, 77(Pt 11), 1451-1459 (2021-11-03)
Thyroglobulin is a homodimeric glycoprotein that is essential for the generation of thyroid hormones in vertebrates. Upon secretion into the lumen of follicles in the thyroid gland, tyrosine residues within the protein become iodinated to produce monoiodotyrosine (MIT) and diiodotyrosine
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