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Merck
CN

T8806

Thymopentin

≥97% (HPLC)

Synonym(s):

TP5, Arg-Lys-Asp-Val-Tyr

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About This Item

Empirical Formula (Hill Notation):
C30H49N9O9
CAS Number:
69558-55-0
Molecular Weight:
679.76
UNSPSC Code:
12352209
PubChem Substance ID:
329826886
NACRES:
NA.26
MDL number:
MFCD00214200

Key Documents

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Product Name

Thymopentin, ≥97% (HPLC)

SMILES string

CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1

InChI key

PSWFFKRAVBDQEG-YGQNSOCVSA-N

assay

≥97% (HPLC)

form

powder

color

white

application(s)

cell analysis

storage temp.

−20°C

Quality Level

200

General description

Thymopentin (TP5) is a pentapeptide produced by the epithelial cells of the thymic cortex and medulla. It consists of thymosin α1 (Tα1).

Biochem/physiol Actions

Thymopentin (TP5) is an immunomodulator, resembling the active site of the thymopoietin. TP5 stimulates cellular immune responses such as T-cell formation, natural killer (NK) cell and macrophage activation, generation of cytokines, and activation of B-cell for antibody production. It also mimics the polypeptide environment of the thymus. TP5 is used to treat conditions like immune deficiency, autoimmune diseases, infections, and cancers. It has a short half-life and is rapidly metabolized in the gastrointestinal tract.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
SLCJ1921
SLBQ5860V
SLBN5912V
SLBC4992V
120M1626V

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Antonia Patruno et al.
Nitric oxide : biology and chemistry, 27(3), 143-149 (2012-06-23)
While thymopentin has been used for many years in the experimental treatment of Sézary syndrome (SS), a rare and very aggressive lymphoma, its mechanism of action is still not known. Herein we show that this peptide acts as an inhibitor
Wendy B London et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(24), 3286-3292 (2011-07-20)
Survival after neuroblastoma relapse is poor. Understanding the relationship between clinical and biologic features and outcome after relapse may help in selection of optimal therapy. Our aim was to determine which factors were significantly predictive of postrelapse overall survival (OS)
Bo Yang et al.
Hematological oncology, 30(3), 115-122 (2012-09-14)
The elderly population is susceptible to haematological malignancies, and these elderly patients are intolerant to cytotoxic drugs. Therefore, the exploration of a safe and reliable strategy exclusive of chemotherapy is critical in improving the prognosis of elderly patients with haematological
E Sundal et al.
Arzneimittel-Forschung, 44(10), 1145-1149 (1994-10-01)
Although the etiology of rheumatoid arthritis (RA) is unknown, there is solid evidence that immunological factors play a pivotal role in its pathogenesis. It seems that a hyporeactivity of local (intraarticular) T-suppressor cells would permit an excessive immune response that
Jing Gao et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 36(4-5), 572-579 (2009-01-13)
Thymopentin (TP5), a synthetic pentapeptide, has been used in clinic as a modulator for immunodeficiences through intramuscular administration. The purpose of this study was to design and evaluate dry powder inhalations (DPIs) for pulmonary delivery of TP5. Dry powder inhalations
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