T8753
2-(p-Toluidino)-6-naphthalenesulfonic acid potassium salt
suitable for fluorescence, BioReagent
Synonym(s):
TNS
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About This Item
Linear Formula:
C17H14NO3SK
CAS Number:
Molecular Weight:
351.46
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Recommended Products
product line
BioReagent
suitability
suitable for fluorescence
storage temp.
2-8°C
SMILES string
[K+].Cc1ccc(Nc2ccc3cc(ccc3c2)S([O-])(=O)=O)cc1
Application
Fluorescent probe for the conformational state of proteins.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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S Shankara Narayanan et al.
Langmuir : the ACS journal of surfaces and colloids, 23(12), 6712-6718 (2007-05-04)
In this contribution, we report studies on nonspecific protein-DNA interactions of an enzyme protein bovine pancreatic alpha-chymotrypsin (CHT) with genomic DNA (from salmon testes) using two biologically common fluorescent probes: 1-anilinonaphthalene-8-sulfonate (ANS) and 2,6-p-toluidinonaphthalene sulfonate (TNS). TNS molecules that are
Ilona Fitos et al.
Biochimica et biophysica acta, 1760(11), 1704-1712 (2006-09-30)
Imatinib is a selective tyrosine kinase inhibitor, successfully used for the treatment of chronic myelogenous leukaemia. Its strong plasma protein binding referred to alpha1-acid glycoprotein (AGP) component was found to inhibit the pharmacological activity. AGP shows genetic polymorphism and the
Guoting Li et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 67(5), 1189-1193 (2006-11-28)
Glu is highly conserved as the first amino acid of E-helix of the EF-hand protein. In this paper, Glu 101, the first amino acid of E-helix of the third EF-hand motif in Euplotes octocarinatus centrin (EoCen) was mutated to be
Zhi-Jun Wang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 70(4), 892-897 (2007-12-07)
The interaction between 2-p-toluidinylnaphthalene-6-sulfonate (TNS) and ciliate Euplotes Octocarinatus centrin (Cen) has been studied by fluorescence spectroscopy. The binding constants of TNS with Cen were measured at different temperature in the 0.01M Hepes, pH 7.4. The binding process is exothermic
Martin Stefl et al.
Analytical biochemistry, 410(1), 62-69 (2010-11-17)
The phasor method of treating fluorescence lifetime data provides a facile and convenient approach to characterize lifetime heterogeneity and to detect the presence of excited state reactions such as solvent relaxation and Förster resonance energy transfer. The method uses a
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