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T8455

Sigma-Aldrich

Tyrosinase Fragment 369-377 human

Synonym(s):

CMM8, OCA1A, OCAIA, SHEP3, TYR

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About This Item

Empirical Formula (Hill Notation):
C42H66N10O16S2
CAS Number:
168650-46-2
Molecular Weight:
1031.16
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

200

Assay

97-100% (HPLC)

form

lyophilized powder

color

white

solubility

deionized water: soluble

UniProt accession no.

P14679

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C42H66N10O16S2/c1-20(2)33(42(67)68)52-39(64)25(10-11-30(44)56)47-40(65)29(19-53)50-38(63)27(13-15-70-5)48-41(66)34(21(3)54)51-31(57)18-45-36(61)28(17-32(58)59)49-37(62)26(12-14-69-4)46-35(60)24(43)16-22-6-8-23(55)9-7-22/h6-9,20-21,24-29,33-34,53-55H,10-19,43H2,1-5H3,(H2,44,56)(H,45,61)(H,46,60)(H,47,65)(H,48,66)(H,49,62)(H,50,63)(H,51,57)(H,52,64)(H,58,59)(H,67,68)

InChI key

MFDQNJLLKIATDB-UHFFFAOYSA-N

Gene Information

human ... TYR(7299)

Amino Acid Sequence

Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val-TFA

Application

Tyrosinase Fragment 369-377 human is a peptide used for controlling the melanin production.

Biochem/physiol Actions

Tyrosinase Fragment 369-377 human is a peptide fragment of enzyme tyrosinase belongs to tyrosinase family. It catalyzes three distinct reactions, the hydroxylation of a monophenol, the dehydrogenation of a catechol and the dehydrogenation of a dihydroxyindole during biosynthesis of melanin.
The Tyrosinase enzyme catalyzes the first steps in the conversion of tyrosine to melanin. This is a membrane bound enzyme expressed in primary and metastatic melanoma lesions. The Tyrosine fragment 369-377 peptide is presented by HLA-A2 antigen to CTLs.

Physical form

Lyophilized from 0.1% aqueous TFA

Other Notes

Lyophilized from 0.1% TFA in H2O

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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A Körner et al.
Science (New York, N.Y.), 217(4565), 1163-1165 (1982-09-17)
The biosynthesis of melanin is initiated by the catalytic oxidation of tyrosine to dopa by tyrosinase in a reaction that requires dopa as a cofactor. Tyrosine then catalyzes the dehydrogenation of dopa to dopaquinone. The subsequent reactions can proceed spontaneously

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