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T8441

L-Threonine

Name: <SC>L</SC>-Threonine
Brand: SIGMA

99.0-101.0%, suitable for cell culture, BioXtra, non-animal source

Synonym(s):

(2S,3R)-2-Amino-3-hydroxybutyric acid

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About This Item

Linear Formula:

CH₃CH(OH)CH(NH₂)CO₂H

CAS Number:

72-19-5

Molecular Weight:

119.12

Beilstein:

1721646

EC Number:

200-774-1

MDL number:

MFCD00064270

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24900531

NACRES:

NA.26

product name

L-Threonine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0%

biological source

non-animal source

Quality Level

300

Agency

USP/NF
meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

product line

BioXtra

Assay

99.0-101.0%

form

powder

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

256 °C (dec.) (lit.)

solubility

H₂O: 1 g/10 mL, clear, colorless

application(s)

pharmaceutical (small molecule)

SMILES string

C[C@@H](O)[C@H](N)C(O)=O

InChI

1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1

InChI key

AYFVYJQAPQTCCC-GBXIJSLDSA-N

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Related Categories

Amino Acids

High-Purity Biochemicals and Reagents

General description

L-Threonine is a naturally occurring amino acid belonging to the aspartate family of amino acids.

Application

L-Threonine has been used for the following :

To study the effect of heat on homoserine kinase activity
In Plackett–Burman analysis and then to study the effect of selected amino acids on monoclonal antibody production in CHO cells
As a substrate to determine the L-threonine dehydrogenase activity
To study the effect of L-Threonine on the growth rate of P. putida, to check for its tolerance towards L-Threonine

Biochem/physiol Actions

L-Threonine is considered to be an essential amino acid. L-Threonine is involved in the synthesis of mucin, a protein supporting intestinal function and integrity. L-Threonine is required for the performance of the immune system. It is also essential for O-linked glycosylation, protein phosphorylation and glycine synthesis.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Homoserine Kinase from Escherichia coli K-12: Properties,
Inhibition by L-Threonine, and Regulation of Biosynthesis

J. THEZE

Journal of Bacteriology, 118(2), 577-581 (1974)

Regulation of L-Threonine Dehydrogenase in Somatic Cell Reprogramming

Chuanchun Han

Stem Cells, 31(5) (2013)

Systems metabolic engineering of Escherichia coli for L?threonine production.

Lee HK, et al.

Molecular Systems Biology, 3(1), 149-149 (2007)

Use of a Plackett-Burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells.

Gonzalez-Leal IJ

Biotechnol. Progress, 27(6), 1709-1717 (2011)

Genome-wide identification of tolerance mechanisms toward p-coumaric acid in Pseudomonas putida

Patricia Calero

Biotechnology and Bioengineering, 115(3), 762-774 (2018)

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