T7189
Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human
>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
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biological source
human
Quality Level
recombinant
expressed in NSO cells
Assay
>95% (SDS-PAGE)
form
lyophilized powder
potency
0.004-0.016 mg per mL ED50
mol wt
52.6 kDa
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TNFRSF1B(7133)
Application
Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human can be used as a test compound for analyzing the interaction between tumor necrosis factor (TNF) and its two soluble receptors by using surface plasmon resonance (SPR) technique.
Biochem/physiol Actions
Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human belongs to TNF family of receptors and mediates the metabolic effects of TNF-α. Tumor Necrosis Factor Soluble Receptor II blocks the TNF-α-induced apoptosis and hence regulates the TNF-α function. It also has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline
Analysis Note
The biological activity is measured by its ability to neutralize the TNF-α mediated cytotoxicity in mouse L-929 cells in the presence of the metabolic inhibitor actinomycin D.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Matthews, N., et al. et al.
Lymphokines and Interferons, A Practical Approach, 221-221 (1987)
Kinetic Analysis of Interaction Between Tumor Necrosis Factor and Its Soluble Receptors.
<BIG>Fan Yang</BIG>
Journal of Analytical Chemistry, 41 (2013)
Begoña Lainez et al.
International immunology, 16(1), 169-177 (2003-12-23)
Tumor necrosis factor (TNF)-alpha is a pleiotropic cytokine involved in a broad spectrum of inflammatory and immune responses including proliferation, differentiation and cell death induction in several cell types. The biological effects of TNF-alpha are mediated via the cell-surface TNF
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