T6319
Anti-TOM22 antibody , Mouse monoclonal
clone 1C9-2, purified from hybridoma cell culture
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Synonym(s):
Anti-Mitochondrial import receptor Tom22, Anti-TOMM22, Anti-Translocase of outer mitochondrial membrane 22 homolog (yeast)
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
1C9-2, monoclonal
form
buffered aqueous solution
mol wt
antigen 22 kDa
species reactivity
human, monkey
should not react with
rodent
concentration
~1 mg/mL
technique(s)
immunocytochemistry: suitable
microarray: suitable
western blot: 0.5-1.0 μg/mL using whole extract of cultured human lymphoma Raji cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TOMM22(56993)
General description
Translocase of outer mitochondrial membrane 22 (TOMM22) is an essential receptor of the mitochondrial import channel. It is characterized with an N-terminal negatively charged region exposed to the cytosol, a putative transmembrane region and a C-terminal intermembrane space region with little negative charge.
Immunogen
membrane fraction from Vero (monkey kidney-derived) cells.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
- Western blotting
Biochem/physiol Actions
Translocase of outer mitochondrial membrane 22 (TOMM22) is a key constituent of TOM complex. It functions as a mitochondrial receptor for the proapoptotic protein Bax (BCL2-associated X protein). TOMM22 interacts with 3-β hydroxysteroid dehydrogenase 2 (3βHSD2) and converts pregnenolone-to-progesterone in steroidogenic cells.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Increased interaction between DJ-1 and the Mi-2/nucleosome remodelling and deacetylase complex during cellular stress.
Opsahl J A., et al.
Proteomics, 10(7), 1494-1504 (2010)
TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.
Bellot G, et al.
Cell Death and Differentiation, 14(4), 785-785 (2007)
An outer mitochondrial translocase, Tom22, is crucial for inner mitochondrial steroidogenic regulation in adrenal and gonadal tissues.
Rajapaksha M, et al.
Molecular and Cellular Biology, 36(6), 1032-1047 (2016)
Andrey Aristov et al.
Nature communications, 9(1), 2409-2409 (2018-06-21)
Single molecule localization microscopy can generate 3D super-resolution images without scanning by leveraging the axial variations of normal or engineered point spread functions (PSF). Successful implementation of these approaches for extended axial ranges remains, however, challenging. We present Zernike Optimized Localization
Kei Okatsu et al.
The Journal of biological chemistry, 288(51), 36372-36384 (2013-11-06)
Parkinsonism typified by sporadic Parkinson disease is a prevalent neurodegenerative disease. Mutations in PINK1 (PTEN-induced putative kinase 1), a mitochondrial Ser/Thr protein kinase, or PARKIN, a ubiquitin-protein ligase, cause familial parkinsonism. The accumulation and autophosphorylation of PINK1 on damaged mitochondria
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