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Safety Information

T6259

Sigma-Aldrich

DL-4-Thiaisoleucine

~98% (TLC)

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Synonym(s):
2-Amino-3-(methylthio)butyric acid
Empirical Formula (Hill Notation):
C5H11NO2S
CAS Number:
Molecular Weight:
149.21
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

Assay

~98% (TLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

CSC(C)C(N)C(O)=O

InChI

1S/C5H11NO2S/c1-3(9-2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)

InChI key

PWDYHRMBGRYCAP-UHFFFAOYSA-N

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Eva S Istvan et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(4), 1627-1632 (2011-01-06)
Intraerythrocytic malaria parasites can obtain nearly their entire amino acid requirement by degrading host cell hemoglobin. The sole exception is isoleucine, which is not present in adult human hemoglobin and must be obtained exogenously. We evaluated two compounds for their
Ian J Clifton et al.
Chembiochem : a European journal of chemical biology, 12(12), 1881-1885 (2011-06-17)
Isopenicillin N synthase (IPNS) catalyses the synthesis of isopenicillin N (IPN), the biosynthetic precursor to penicillin and cephalosporin antibiotics. IPNS is a non-heme iron(II) oxidase that mediates the oxidative cyclisation of the tripeptide δ-L-α-aminoadipoyl-L-cysteinyl-D-valine (ACV) to IPN with a concomitant
M Green
The Journal of biological chemistry, 257(15), 9039-9042 (1982-08-10)
The incorporation of the leucine analog, beta-hydroxyleucine, or the isoleucine analog, 4-thiaisoleucine, into the MPOC-46B kappa chain interfered with the processing of the oligosaccharide moiety of newly synthesized light chains. Analog-containing chains were secreted with endo-beta-N-acetylglucosaminidase H-sensitive oligosaccharides instead of

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