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T5442

Sigma-Aldrich

Anti-ADAM-17 (TACE), C-Terminal antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-TACE, Anti-TNF-α Converting Enzyme

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About This Item

MDL number:
MFCD03096588
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 80-130 kDa (wide band representing mature protein, precursor and glycosylated TACE)

species reactivity

mouse, rat, human

concentration

~0.5 mg/mL

technique(s)

microarray: suitable
western blot: 0.25-1 μg/mL using HeLa or Jurkat cell lysates

UniProt accession no.

P78536

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... ADAM17(6868)
mouse ... Adam17(11491)
rat ... Adam17(57027)

Immunogen

synthetic peptide corresponding to the C-terminal amino acids 807-823 of human TNF-α converting enzyme (TACE). This peptide differs from mouse and rat by only one amino acid.

Physical form

Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
037K1531
047K1423
021K0225
090K1002

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Anna A Pimenova et al.
PloS one, 9(1), e87014-e87014 (2014-01-28)
Proteolytic processing of the amyloid precursor protein (APP) by the β- and γ-secretases releases the amyloid-β peptide (Aβ), which deposits in senile plaques and contributes to the etiology of Alzheimer's disease (AD). The α-secretase cleaves APP in the Aβ peptide
C Y Chua et al.
Oncogene, 35(6), 738-747 (2015-04-22)
Insulin-like growth factor binding protein 2 (IGFBP2) is a pleiotropic oncogenic protein that has both extracellular and intracellular functions. Despite a clear causal role in cancer development, the tumor-promoting mechanisms of IGFBP2 are poorly understood. The contributions of intracellular IGFBP2

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