T5330
Tanshinone I
≥98% (HPLC)
Synonym(s):
Tanshinon I, Tanshinone A, Tanshinquinone I
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About This Item
Empirical Formula (Hill Notation):
C18H12O3
CAS Number:
Molecular Weight:
276.29
MDL number:
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.25
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
red
solubility
DMSO: 1 mg/mL
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
Cc1coc2-c3ccc4c(C)cccc4c3C(=O)C(=O)c12
InChI
1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
InChI key
AIGAZQPHXLWMOJ-UHFFFAOYSA-N
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General description
Tanshinone I (Tan I) is a phenolic compound primarily isolated from Danshen. It has an abietane diterpene norditerpenoid o-quinones structure. Tan I have poor water solubility.
Application
Tanshinone 1 has been used:
- to test its hematopoiesis effects on human leukemia cell lines and zebrafish xenograft models
- to study its anti-cancer effects on two breast cancer cell lines (MCF7 and MDA-MB-23)
- as a reference standard to quantify the bioactive component S. miltiorrhiza extract (SME) using high-performance liquid chromatography (HPLC)
Biochem/physiol Actions
Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Modulates or prevents breast cancer metastasis by regulating adhesion molecules. Anti-inflammatory.
TanshinoneI is extensively studied for its anticancer properties, it was reported to inhibit cancer cell invasion, metastasis, and migration and is a potent antitumor agent. It also displays antibacterial, neuroprotective, memory-enhancing, and cardioprotective activities.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Xiao Zhang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 595-603 (2013-01-29)
The aim of this study was to develop novel multiple agents loaded poly (D,L-lactide-co-glycolide acid) (PLGA) nanoparticles (NPs) and evaluate their potential for brain delivery via inner ear administration. PLGA NPs loaded with salvianolic acid B (Sal B), tanshinone IIA
Sun-Mi Yun et al.
Biological & pharmaceutical bulletin, 36(2), 208-214 (2013-02-02)
Aim of this study was to identify the molecular mechanisms of tanshinone IIA-induced apoptosis in chronic myelogenous leukemia (CML) cells. Cytotoxicity of tanshinone IIA was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Our data demonstrate that tanshinone IIA induced apoptosis by
Hua-Mei Wang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(4), 559-563 (2013-05-30)
To prepare panax notoginseng saponins-tanshinone II(A) composite particles for pulmonary delivery, in order to explore a dry powder particle preparation method ensuring synchronized arrival of multiple components of traditional Chinese medicine compounds at absorption sites. Panax notoginseng saponins-tanshinone II(A) composite
Paul Chan et al.
The American journal of Chinese medicine, 40(6), 1307-1319 (2012-12-12)
The injury of endothelial cell is the critical event of vascular disease. In endothelial cell, oxidative stress is regarded as critical to pathogenic factors in endothelial cell injury and apoptosis. Tanshinone IIA is the main effective component of Salvia miltiorrhiza
Hui Ma et al.
The American journal of Chinese medicine, 41(1), 197-210 (2013-01-23)
Natural product Tanshinone IIA (TanIIA) induces apoptosis and differentiation in hepatocellular carcinoma (HCC) cells, but its clinical use is limited due to poor water solubility and lack of appropriate formulations for drug delivery. In this study, we capsulated TanIIA into
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