T5125
Thimerosal
97.0-101.0% (on dried substance, titration)
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Synonym(s):
2-(Ethylmercuriomercapto)benzoic acid sodium salt, Ethylmercurithiosalicylic acid sodium salt, Mercury-([o-carboxyphenyl]thio)ethyl sodium salt, Sodium ethylmercurithiosalicylate
Linear Formula:
2-(C2H5HgS)C6H4CO2Na
CAS Number:
Molecular Weight:
404.81
Beilstein:
8169555
EC Number:
MDL number:
UNSPSC Code:
51101500
PubChem Substance ID:
NACRES:
NA.21
Recommended Products
Quality Level
Assay
97.0-101.0% (on dried substance, titration)
form
powder or crystals
color
white to faint beige
mp
234-237 °C (dec.) (lit.)
solubility
1 g/L at 20 °C
Mode of action
enzyme | inhibits
storage temp.
room temp
SMILES string
[Na+].CC[Hg]Sc1ccccc1C([O-])=O
InChI
1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2
InChI key
RTKIYNMVFMVABJ-UHFFFAOYSA-L
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Biochem/physiol Actions
Thimerosal is a sulfhydryl (thiol) oxidizing reagent capable of inhibiting a wide range of sulfhydryl-dependent enzymes and proteins such as PI3-kinase-dependent methionine synthase, glutamate transport receptors, and Na++K+ dependent ATPases.
Features and Benefits
- Meets USP/EP testing specifications
- High-quality chemical, suitable for a wide variety of research applications.
Other Notes
As part of the corporation global plan to support the Minamata Convention eliminating mercury-containing compounds, as of January 2021 customers will be required to provide an End-Use Declaration. The sales of thimerosal will be restricted for approved applications only, such as preservative in vaccine manufacturing, preservative in eye cosmetics, research use within academia (excluding preservation intent) and as reference material only. The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act , European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.
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Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
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Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral
Target Organs
Kidney
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
危险化学品
Certificates of Analysis (COA)
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Pan-Chyr Yang et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 111(6), 333-339 (2012-07-04)
This study evaluated the immune response elicited by two formulations of an AS03(A)-adjuvanted H5N1 A/Indonesia/05/2005 prepandemic influenza vaccine, developed using manufacturing processes with or without thiomersal. In addition, it also evaluated compliance to the Centre for Biologics Evaluation and Research
Alberto Eugenio Tozzi et al.
Developmental medicine and child neurology, 54(9), 843-848 (2012-05-18)
The aim of this article was to explore the effect of duration of breastfeeding on neurocognitive development. The long-term effect of breastfeeding on neurodevelopment was examined through a battery of neuropsychological tests in 1403 children (693 females, 710 males; mean
R Chalghoumi et al.
Poultry science, 87(1), 32-40 (2007-12-15)
The present study was an attempt to raise hen egg yolk Ig (IgY) simultaneously directed against Salmonella Enteritidis (SE) and Salmonella Typhimurium (ST) in the same egg yolk. The immunopotentiating effect of 2 different adjuvants -- Freund's adjuvants (FA) and
L K Ball et al.
Pediatrics, 107(5), 1147-1154 (2001-05-23)
On July 7, 1999, the American Academy of Pediatrics and the US Public Health Service issued a joint statement calling for removal of thimerosal, a mercury-containing preservative, from vaccines. This action was prompted in part by a risk assessment from
José G Dórea
Clinica chimica acta; international journal of clinical chemistry, 411(21-22), 1580-1586 (2010-07-20)
To compare epidemiological studies dealing with neurological issues (compatible with Hg toxicity) linked to exposing newborns and infants to intramuscular doses of preservative-Hg resulting from vaccination with thimerosal-containing vaccines (TCV). Major databases were searched for studies that addressed neurodevelopment outcomes
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