T5050
Transforming Growth Factor-β1 from porcine platelets
≥97% (SDS-PAGE), recombinant, powder, suitable for cell culture
Synonym(s):
TGF-β1
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Product Name
Transforming Growth Factor-β1 from porcine platelets, TGF-β1, powder, suitable for cell culture
biological source
Porcine (Platelets)
Quality Level
Assay
≥97% (SDS-PAGE)
form
powder
potency
0.01-0.1 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
protein 25 kDa
packaging
pkg of 1 μg
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg
UniProt accession no.
storage temp.
−20°C
Gene Information
pig ... TGFB1(397078)
General description
The TGFB (transforming growth factor-β) gene is mapped to pig (Sus scrofa) chromosome between 6q11-q21. In mammals, TGFβ is present in three isoforms (TGFβ1, TGFβ2 and TGFβ3), of which TGFβ1 is predominant.
Application
Transforming Growth Factor-β1 from porcine platelets has been used in chondrogenic differentiation. It has also been used in immobilization process.
Biochem/physiol Actions
Transforming growth factor-β1 (TGF-β) is a multifunctional polypeptide growth factor. TGF-β mediates cell proliferation, differentiation and migration. Important cellular functions such as inflammation, extracellular matrix synthesis, epithelial restoration and developmental processes are also controlled by TGF-β. TGF-β controls the regulation of enamel mineralization in porcine. TGF-β is associated with the development of idiopathic pulmonary fibrosis (a chronic lung disease). TGF-β promotes epithelial-mesenchymal transition (EMT) and contributes to proliferation and metastasis of cancer. The TGF-β induced EMT is observed in kidney fibrosis. TGF-β is stimulates regeneration of intestinal tissue.
Transforming growth factor-β1 (TGF-β1) is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2.
Physical form
Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.05 mg bovine serum albumin per μg cytokine.
Analysis Note
The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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TGF-β1 autocrine signalling and enamel matrix components
Kinoshita SK, et al.
Scientific Reports (2016)
TGF-β1 immobilized tri-co-polymer for articular cartilage tissue engineering.
Chou CH, et al.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 77(2), 338-348 (2006)
Developmental Changes of TGF-β1 and Smads Signaling Pathway in Intestinal Adaption of Weaned Pigs
Xiao K, et al.
PLoS ONE, 9(8) (2014)
Isolation, culture and chondrogenic differentiation of canine
adipose tissue- and bone marrow-derived mesenchymal stem
cells?a comparative study
adipose tissue- and bone marrow-derived mesenchymal stem
cells?a comparative study
Reich CM, et al.
Veterinary Research Communications, 36, 139-148 (2012)
Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β
Ding Q, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 312(6), L926-L935 (2017)
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