T5050
Transforming Growth Factor-β1 from porcine platelets
≥97% (SDS-PAGE), recombinant, powder, suitable for cell culture
Synonym(s):
TGF-β1
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Product Name
Transforming Growth Factor-β1 from porcine platelets, TGF-β1, powder, suitable for cell culture
biological source
Porcine (Platelets)
Quality Level
Assay
≥97% (SDS-PAGE)
form
powder
potency
0.01-0.1 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
protein 25 kDa
packaging
pkg of 1 μg
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg
UniProt accession no.
storage temp.
−20°C
Gene Information
pig ... TGFB1(397078)
General description
The TGFB (transforming growth factor-β) gene is mapped to pig (Sus scrofa) chromosome between 6q11-q21. In mammals, TGFβ is present in three isoforms (TGFβ1, TGFβ2 and TGFβ3), of which TGFβ1 is predominant.
Application
Transforming Growth Factor-β1 from porcine platelets has been used in chondrogenic differentiation. It has also been used in immobilization process.
Biochem/physiol Actions
Transforming growth factor-β1 (TGF-β) is a multifunctional polypeptide growth factor. TGF-β mediates cell proliferation, differentiation and migration. Important cellular functions such as inflammation, extracellular matrix synthesis, epithelial restoration and developmental processes are also controlled by TGF-β. TGF-β controls the regulation of enamel mineralization in porcine. TGF-β is associated with the development of idiopathic pulmonary fibrosis (a chronic lung disease). TGF-β promotes epithelial-mesenchymal transition (EMT) and contributes to proliferation and metastasis of cancer. The TGF-β induced EMT is observed in kidney fibrosis. TGF-β is stimulates regeneration of intestinal tissue.
Transforming growth factor-β1 (TGF-β1) is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2.
Physical form
Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.05 mg bovine serum albumin per μg cytokine.
Analysis Note
The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β
Ding Q, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 312(6), L926-L935 (2017)
Isolation, culture and chondrogenic differentiation of canine
adipose tissue- and bone marrow-derived mesenchymal stem
cells?a comparative study
adipose tissue- and bone marrow-derived mesenchymal stem
cells?a comparative study
Reich CM, et al.
Veterinary Research Communications, 36, 139-148 (2012)
Developmental Changes of TGF-β1 and Smads Signaling Pathway in Intestinal Adaption of Weaned Pigs
Xiao K, et al.
PLoS ONE, 9(8) (2014)
Effect of Conceptus on Transforming Growth Factor (TGF) β1 mRNA Expression and Protein Concentration in the Porcine Endometrium?In Vivo and In Vitro Studies
Blitek A, et al.
Journal of Reproduction and Development, 59(6), 512-519 (2013)
TGF-β1 immobilized tri-co-polymer for articular cartilage tissue engineering.
Chou CH, et al.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 77(2), 338-348 (2006)
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