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Safety Information

T4687

Sigma-Aldrich

Thimerosal

meets USP testing specifications

Synonym(s):

2-(Ethylmercuriomercapto)benzoic acid sodium salt, Ethylmercurithiosalicylic acid sodium salt, Mercury-([o-carboxyphenyl]thio)ethyl sodium salt, Sodium ethylmercurithiosalicylate

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About This Item

Linear Formula:
2-(C2H5HgS)C6H4CO2Na
CAS Number:
54-64-8
Molecular Weight:
404.81
Beilstein:
8169555
EC Number:
200-210-4
MDL number:
MFCD00013062
UNSPSC Code:
12352200
PubChem Substance ID:
24900219

biological source

synthetic (Organic)

Agency

USP/NF
meets USP testing specifications

form

powder

mp

234-237 °C (dec.) (lit.)

cation traces

Hg: ≤0.70% (ions)

Mode of action

enzyme | inhibits

SMILES string

[Na+].CC[Hg]Sc1ccccc1C([O-])=O

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

InChI key

RTKIYNMVFMVABJ-UHFFFAOYSA-L

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Biochem/physiol Actions

Thimerosal is a sulfhydryl (thiol) oxidizing reagent capable of inhibiting a wide range of sulfhydryl-dependent enzymes and proteins such as PI3-kinase-dependent methionine synthase, glutamate transport receptors, and Na++K+ dependent ATPases.

Other Notes

As part of the corporation global plan to support the Minamata Convention eliminating mercury-containing compounds, as of January 2021 customers will be required to provide an End-Use Declaration. Sales of thimerosal will be restricted for approved applications only.
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Disclaimer

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

Target Organs

Kidney

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品
非剧毒-急性毒性1

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Certificates of Analysis (COA)

Lot/Batch Number
0000106229
0000099160
0000099158
SLCC3222
SLBR8037V

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Pan-Chyr Yang et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 111(6), 333-339 (2012-07-04)
This study evaluated the immune response elicited by two formulations of an AS03(A)-adjuvanted H5N1 A/Indonesia/05/2005 prepandemic influenza vaccine, developed using manufacturing processes with or without thiomersal. In addition, it also evaluated compliance to the Centre for Biologics Evaluation and Research
Dorota Mrozek-Budzyn et al.
Neurotoxicology and teratology, 34(6), 592-597 (2012-10-17)
Despite the common use of Thimerosal as a preservative in childhood vaccines since the 1930s, there are not many studies on ethylmercury toxicokinetics and toxicodynamics in infants. The knowledge of ethylmercury's potential adverse effects is derived mostly from parallel methylmercury
Alicia Bazzano et al.
American journal on intellectual and developmental disabilities, 117(3), 233-242 (2012-06-22)
Although the assertion of a link between vaccines and autism has been scientifically rejected, the theory continues to be popular and may influence the attitudes of parents of children with autism spectrum disorders. The authors sought to assess how often
Alberto Eugenio Tozzi et al.
Developmental medicine and child neurology, 54(9), 843-848 (2012-05-18)
The aim of this article was to explore the effect of duration of breastfeeding on neurocognitive development. The long-term effect of breastfeeding on neurodevelopment was examined through a battery of neuropsychological tests in 1403 children (693 females, 710 males; mean
Anna Kirkland
Social studies of science, 42(2), 237-261 (2012-08-02)
That vaccines do not cause autism is now a widely accepted proposition, though a few dissenters remain. An 8-year court process in the US federal vaccine injury compensation court ended in 2010 with rulings that autism was not an adverse
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