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T4382

Sigma-Aldrich

apo-Transferrin human

powder, ≥98% (agarose gel electrophoresis)

Synonym(s):

Human transferrin, Siderophilin

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About This Item

CAS Number:
11096-37-0
EC Number:
234-318-8
MDL number:
MFCD00130536
UNSPSC Code:
12352202
NACRES:
NA.75

biological source

human

Quality Level

200

Assay

≥98% (agarose gel electrophoresis)

form

powder

mol wt

76-81 kDa

Iron content

≤0.005%

technique(s)

cell culture | mammalian: suitable

impurities

HIV and HBsAg, source material tested negative

solubility

H2O: 50 mg/mL

UniProt accession no.

P02787

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TF(7018)

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General description

Apo-transferrin human is a glycoprotein, possessing homologous carboxyl and amino domain. Both the domain binds to one molecule of iron. Only 30% of transferrin is saturated with iron in the amino domain. Apo-transferrin in human is encoded by the gene TF which is localized on human chromosome 3q22.1.

Application

Apo-Transferrin human has been used:
  • to determine the competitive binding of bismuth to albumin and transferrin by fast performance liquid chromatography (FPLC)
  • to study titanium-transferrin complex by electrochemical method
  • in the preparation of transferrin solution and in the formation of conjugates with ruthenium-complexes for cellular viability studies

Biochem/physiol Actions

Apo-transferrin is an iron transport protein. The concentration of transferrin in blood plasma is about 35 μM. Transferrin also functions in the transport of therapeutic, diagnostic and toxic ions like Ga3+, Ru3+ and Al3+. Polymorphism in TF gene has pathological implications in Parkinson′s disease.
Apo-transferrin is required for the survival and differentiation of oligodendroglial cells.

Other Notes

Non-heme iron-transport protein.

Linkage

Similar to T 2252

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000411573
0000411573
0000401047
0000394687
0000371761

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the carbohydrate content of human transferrin?

    We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.

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Binding of bismuth to serum proteins: implication for targets of Bi (III) in blood plasma
Sun H and Szeto KY
Journal of Inorganic Biochemistry, 94(1-2), 114-120 (2003)
Pooled analysis of iron-related genes in Parkinson's disease: association with transferrin
Rhodes SL, et al.
Neurobiology of Disease, 62, 172-178 (2014)
Direct electrochemistry of the Ti (IV)-transferrin complex: Probing into the transport of Ti (IV) by human serum transferrin
Shen M, et al.
Electrochemical Communications, 13(2), 114-116 (2011)
New polydentate Ru (III)-Salan complexes: Synthesis, characterization, anti-tumour activity and interaction with human serum proteins
Matos CP, et al.
Inorgorganica Chimica Acta, 394, 616-626 (2013)
Junko Iijima et al.
Fukushima journal of medical science, 67(2), 64-70 (2021-08-11)
Spontaneous intracranial hypotension (SIH) is caused by cerebrospinal fluid (CSF) leakage. Patients with SIH experience postural headaches, nausea, etc., due to CSF hypovolemia. Imaging studies and clinical examinations, such as radioisotope (RI) scintigraphy, are useful for diagnosing SIH. However, 20-30%
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