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Merck
CN

T4264

Tetrahydrozoline hydrochloride

≥98% (HPLC)

Synonym(s):

4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole monohydrochloride, Tetryzoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C13H16N2 · HCl
CAS Number:
522-48-5
Molecular Weight:
236.74
NACRES:
NA.77
PubChem Substance ID:
24278736
UNSPSC Code:
12352200
EC Number:
208-329-3
MDL number:
MFCD00058029
Assay:
≥98% (HPLC)
Quality level:
200

Key Documents

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Product Name

Tetrahydrozoline hydrochloride, ≥98% (HPLC)

InChI

1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H

InChI key

BJORNXNYWNIWEY-UHFFFAOYSA-N

SMILES string

Cl.C1CC(C2=NCCN2)c3ccccc3C1

assay

≥98% (HPLC)

solubility

H2O: freely soluble
alcohol: freely soluble
chloroform: very slightly soluble
diethyl ether: insoluble

originator

Novartis

Quality Level

200

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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Biochem/physiol Actions

Tetrahydrozoline is an α-adrenergic agonist and an imidazoline derivative. It plays a crucial role in the constriction of conjunctival blood vessels. Tetrahydrozoline is a common component of nasal and eye drop formulations.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000493073
0000493073
0000436956
0000436956
SLCB7381

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Henry A Spiller et al.
Journal of forensic sciences, 57(3), 835-838 (2012-01-04)
Drug-facilitated sexual assault (DFSA) has been defined as the use of a chemical agent to facilitate a sexual assault. We report two cases of the use of tetrahydrozoline for DFSA. We believe this is the first report with urinary quantification
Mary E Carr et al.
Clinical toxicology (Philadelphia, Pa.), 49(9), 810-814 (2011-10-07)
No information exists on therapeutic or toxic concentrations of tetrahydrozoline, which has been reported to be used in drug facilitated sexual assaults. The primary aim of this investigation was to establish baseline therapeutic serum and urine concentrations in a sample
Aaron Daggy et al.
Veterinary and human toxicology, 45(4), 210-212 (2003-07-29)
Visine, an over-the-counter, tetrahydrozoline topical ophthalmic decongestant, possesses central and peripheral alpha2-adrenergic properties. We present a case of accidental pediatric oral exposure with resultant neurological and cardiovascular complications. Visine is not marketed in childproof containers, despite the potential severity of
Engin Bilge Ozgurhan et al.
BioMed research international, 2013, 481843-481843 (2013-07-19)
To evaluate the effect of a fluorometholone/tetrahydrozoline fixed combination on conjunctival graft morphology after primary pterygium excision. The patients who underwent pterygium excision with conjunctival autograft transplantation were randomized into three groups based on postoperative medications as the fluorometholone/tetrahydrozoline group
Luciano Giardino et al.
Journal of endodontics, 33(7), 852-855 (2007-09-07)
The aim of this study was to compare the antimicrobial efficacy of 5.25% NaOCl, BioPure MTAD (Dentsply Tulsa Dental, Johnson City, TN), and Tetraclean (Ogna Laboratori Farmaceutici, Milano, Italy) against Enterococcus faecalis biofilm generated on cellulose nitrate membrane filters. After
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