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Key Documents

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T4069

Sigma-Aldrich

JC-1

≥97% purity, solid

Synonym(s):

5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide, CBIC2(3)

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About This Item

Empirical Formula (Hill Notation):
C25H27Cl4IN4
CAS Number:
3520-43-2
Molecular Weight:
652.23
MDL number:
MFCD00188475
UNSPSC Code:
12171500
PubChem Substance ID:
24900193
NACRES:
NA.47

Product Name

JC-1, powder or solid (Crystals)

Assay

≥97%

Quality Level

100

form

powder or solid (Crystals)

technique(s)

titration: suitable

color

faint red to very dark red

ε (extinction coefficient)

≥175000 at 511-517 nm in methanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[I-].CCN1C(=C\C=C\c2n(CC)c3cc(Cl)c(Cl)cc3[n+]2CC)/N(CC)c4cc(Cl)c(Cl)cc14

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D-2-脱氧葡萄糖 ≥98% (GC), crystalline

D8375

D-2-脱氧葡萄糖

D-2-脱氧葡萄糖 ≥98% (GC), BioXtra

D3179

D-2-脱氧葡萄糖

甲基α-D-吡喃葡萄糖苷 ≥99% (GC)

M9376

甲基α-D-吡喃葡萄糖苷

biological source

synthetic (organic)

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic (organic)

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, inhibition assay: suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

assay

≥99% (GC)

assay

≥98% (GC)

assay

≥98% (GC)

assay

≥99% (GC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

solubility

H2O: soluble 330 mg/mL, clear, colorless

solubility

H2O: 0.250 g/5mL

solubility

H2O: 1 M at 20 °C, clear, colorless

solubility

water: 50 mg/mL, clear, colorless

form

crystalline

form

crystalline

form

powder

form

powder

Application

A dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent (λex 520 nm) monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent (λem 596 nm ) "J-aggregates," which exhibit broad excitation and very narrow emission spectra. The ratio of red to green fluorescence of JC-1 is dependent only on membrane potential, and not influenced by mitochondrial size, shape, or density.
The cyanine dye[1] JC-1 has been used to determine mitochondrial transmembrane potential.[2][3][4]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCX2204
    MKCW5291
    MKCT7568
    MKCT1231
    MKCS4169

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    Xianbin Cao et al.
    Cellular signalling, 62, 109337-109337 (2019-06-08)
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    Sulfated polysaccharide-protein complex sensitizes doxorubicin-induced apoptosis of breast cancer cells in vitro and in vivo
    Jie Wang
    Experimental and Therapeutic Medicine (2016)
    Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
    Chunyan Xue
    Oncology Letters (2016)
    Sudhir Pandey et al.
    American journal of physiology. Cell physiology, 317(2), C235-C243 (2019-05-23)
    Doxorubicin (DOX) is an anthracycline antibiotic commonly employed for the treatment of various cancers. However, its therapeutic uses are hampered by side effects associated with cumulative doses during the course of treatment. Whereas deregulation of autophagy in the myocardium has
    JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry
    A Perelman
    Cell Death & Disease (2012)
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