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Merck
CN

T3952

Anti-β-Tubulin III Antibody

rabbit polyclonal

Synonym(s):

Anti-Tuj 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01323870

Key Documents

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Product Name

Anti-β-Tubulin III antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:500-1:1,000

UniProt accession no.

Q13509

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... TUBB3(10381)
mouse ... Tubb3(22152)
rat ... Tubb3(246118)

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Application

Anti-β-Tubulin III antibody is suitable for use in flow cytometry (1:200-1:500), immunohistochemistry (1:100-1:200), immunoblot (approx. 50kDa) and western blot (1:500-1:1,000).
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)

Biochem/physiol Actions

Missense mutations in the tubulin β 3 class III gene (TUBB3) impacts microtubule organisation in neuronal cells and contributes to neurological disorders. Mutations in TUBB3 is implicated in tubulopathies contributing to malformations in developing fetus.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Microtubules are heterodimeric proteins that comprise of α- and β-tubulins. β-tubulins have several different isotypes . β-Tubulin III is a marker for nerve cell differentiation, as well as for venous and lymphatic valves . Changes in β-tubulin III expression have been associated with medulloblastoma
Anti-tubulin antibodies are useful to study the localization of tubulin proteins. Anti-β-Tubulin III antibody is specific for β-Tubulin III in humans.
Tubulin β 3 class III (TUBB3) is mapped to human chromosome 16q24.3.

Immunogen

synthetic peptide corresponding to residues 151-165 of human β-Tubulin III.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL8834
SLCG2974
SLBX1889
SLBS8820
SLBS1490V

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Jasmin Bartl et al.
Journal of molecular psychiatry, 1(1), 5-5 (2013-01-01)
The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we
Sanaz Yahyanejad et al.
Oncotarget, 7(27), 41251-41264 (2016-05-18)
Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. The current standard of care includes surgery followed by radiotherapy (RT) and chemotherapy with temozolomide (TMZ). Treatment often fails due to the radiation resistance and intrinsic or acquired
Mutations in tubulin genes are frequent causes of various foetal malformations of cortical development including microlissencephaly.
Fallet-Bianco C, et al.
Acta Neuropathologica Communications, 2(1), 69-69 (2014)
Prognostic utility of beta-tubulin isotype III and correlations with other molecular and clinicopathological variables in patients with early breast cancer: a translational Hellenic Cooperative Oncology Group (HeCOG) study.
Pentheroudakis G, et al.
Breast Cancer Research and Treatment, 127(1), 179-193 (2011)
Valentina Caracciolo et al.
Journal of cellular physiology, 223(2), 519-529 (2010-02-18)
In previous studies, we have shown overexpression and ectopic subcellular distribution of gamma-tubulin and betaIII-tubulin in human glioblastomas and glioblastoma cell lines (Katsetos et al., 2006, J Neuropathol Exp Neurol 65:455-467; Katsetos et al., 2007, Neurochem Res 32:1387-1398). Here we
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Data Sheet - T3952

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