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T3034

Sigma-Aldrich

Trehalose 6,6′-dimycolate from Mycobacterium bovis

≥97% 6,6′-mycolate esters basis

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Synonym(s):
6,6′-Di-O-mycoloyl-α,α-trehalose from Mycobacterium bovis, Cord factor from Mycobacterium bovis
CAS Number:
61512-20-7
MDL number:
MFCD00081533
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

bacterial (Mycobacterium bovis)

Assay

≥97% 6,6′-mycolate esters basis

form

powder

optical activity

[α]25/D 32 to 35 °, c = 1% (w/v) in chloroform/methanol/water (10:9:1)

storage temp.

−20°C

InChI

1S/C130H250O15/c1-5-9-13-17-21-25-29-33-37-41-43-45-47-49-51-53-57-61-65-71-81-89-97-105-117(131)116(104-96-88-80-74-73-78-86-94-102-114-108-112(114)100-92-84-76-68-63-59-55-40-36-32-28-24-20-16-12-8-4)128(140)142-110-120-122(134)124(136)126(138)130(144-120)145-129-125(137)123(135)121(133)119(143-129)109-141-127(139)115(103-95-87-79-70-64-60-56-52-50-48-46-44-42-38-34-30-26-22-18-14-10-6-2)118(132)106-98-90-82-72-66-69-77-85-93-101-113-107-111(113)99-91-83-75-67-62-58-54-39-35-31-27-23-19-15-11-7-3/h111-126,129-138H,5-110H2,1-4H3

InChI key

DJUMKUNMJWRLAX-UHFFFAOYSA-N

Biochem/physiol Actions

Cord factor is a glycolipid released from Mycobacterium that becomes toxic and antigenic when it interacts with cell surface lipids. It activates macrophages to release inflammatory cytokines and induces thymic atrophy and granuloma formation in lung and other organs. It is responsible for the necrosis and cavitation observed in secondary tuberculosis.

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

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Yasunobu Miyake et al.
Journal of immunology (Baltimore, Md. : 1950), 194(11), 5366-5374 (2015-04-19)
C-type lectin receptors expressed in APCs are recently defined pattern recognition receptors that play a crucial role in immune responses against pathogen-associated molecular patterns. Among pathogen-associated molecular patterns, cord factor (trehalose-6,6'-dimycolate [TDM]) is the most potent immunostimulatory component of the

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