T2830
Tomatine hydrate
≥95% (HPLC)
Synonym(s):
Lycopersicin, NSC 234440, NSC 9223, Spirosolane, a-Tomatine, alpha-tomatine, b-D-galactopyranoside deriv
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About This Item
Empirical Formula (Hill Notation):
C50H83NO21 · xH2O
CAS Number:
Molecular Weight:
1034.19 (anhydrous basis)
EC Number:
UNSPSC Code:
12352200
Assay
≥95% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
room temp
Application
Tomatine has been used as a standard for HPLC-based determination of tomatine from red and green tomatoes1. It has also been used to study its teratogenic effect using frog embryos2.
Biochem/physiol Actions
When the pure compounds were isolated, alpha-Tomatine was highly effective in inhibiting all of the cell lines, whereas dehydrotomatine, tomatidenol, and tomatidine had little, if any, effect on cell inhibition. It had been previously shown that commercial tomatine, which is customarily an approximate 10:1 mixture of α-tomatine and dehydrotomatine, strongly inhibits the growth of both colon and liver cancer cells.
Preparation Note
Tomatine hydrate is soluble in DMSO at a concentration that is greater than 20 mg/ml.
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Jianghong Guo et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 35(7), 882-884 (2010-06-26)
To develop an HPLC method for determination of tomatine in the dried Solanum cathayanum of China Hubei Enshi. The analysis was performed on a YMC-Pack ODS-AA column (4. 6 mm x 150 mm, 5 microm) eluted with acetonitrile and water
Gabriel Mitchell et al.
Antimicrobial agents and chemotherapy, 55(5), 1937-1945 (2011-03-02)
Small-colony variants (SCVs) often are associated with chronic Staphylococcus aureus infections, such as those encountered by cystic fibrosis (CF) patients. We report here that tomatidine, the aglycon form of the plant secondary metabolite tomatine, has a potent growth inhibitory activity
Min-Wu Chao et al.
PloS one, 7(9), e44093-e44093 (2012-09-13)
α-Tomatine, a tomato glycoalkaloid, has been reported to possess antibiotic properties against human pathogens. However, the mechanism of its action against leukemia remains unclear. In this study, the therapeutic potential of α-tomatine against leukemic cells was evaluated in vitro and
Yandong Shi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(17), 4646-4656 (2012-06-27)
The aim of this study was to assess the activity of hedgehog signaling pathway in malignant pleural mesothelioma (MPM). The expression of hedgehog signaling components was assessed by quantitative PCR and in situ hybridization in 45 clinical samples. Primary MPM
Hideyuki Manabe et al.
Chemical & pharmaceutical bulletin, 59(11), 1406-1408 (2011-11-02)
In the conventional method of mixer blending extraction, the yields of the tomato-saponin, esculeoside A, in the mini and middy tomatoes were found to be 0.043% and 0.046%, respectively. In order to improve the yields, we attempted a more efficient
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