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T1157

Sigma-Aldrich

(+)-α-Tocopherol acetate

BioReagent, suitable for insect cell culture, ~1360 IU/g

Synonym(s):

Vitamin E acetate

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About This Item

Empirical Formula (Hill Notation):
C31H52O3
CAS Number:
58-95-7
Molecular Weight:
472.74
EC Number:
200-405-4
MDL number:
MFCD00072052
UNSPSC Code:
12352205
eCl@ss:
34058007
PubChem Substance ID:
24899940
NACRES:
NA.75

biological source

plant

Quality Level

200

description

Synthesized from natural α-tocopherol

product line

BioReagent

form

liquid (or semi-solid)

specific activity

~1360 IU/g

mol wt

Mw 472.74 g/mol

purified by

crystallization

technique(s)

cell culture | insect: suitable

color

white to yellow

solubility

chloroform: soluble 50 mg/mL, clear, colorless to yellow

storage temp.

room temp

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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General description

α-Tocopherol acetate is a semisynthetic acetate ester of naturally occurring α-tocopherol.

Application

(+)-α-Tocopherol acetate has been used:
  • as a supplement in the human embryonic kidney cells (HEK 293) to assess its impact on cell growth
  • as a component of Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 (DMEM/F12) for immortalized chondrocyte cell line
  • as a component of serum-free medium for human colon tissue organ culture
  • to test its antioxidant effects on cow articular chondrocytes

Use in insect cell culture applications as an antioxidant.

Biochem/physiol Actions

α-Tocopherol acetate or vitamin E-acetate has antioxidant properties and reduces lipid peroxidation. However, vitamin E acetate on pyrolysis leads to the generation of carcinogens like alkenes and benzenes.

Caution

Since the M.P. is about 25 °C this preparation is usually an oil. Does not air oxidize.

Hazard Statements

H413

Precautionary Statements

P273 - P501

Hazard Classifications

Aquatic Chronic 4

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments.
Laura Cervera et al.
BMC proceedings, 5 Suppl 8, P126-P126 (2012-03-01)
Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 47(1), 32-38 (2010-11-26)
We have recently shown that a multi-mineral extract from the marine red algae, Lithothamnion calcareum, suppresses colon polyp formation and inflammation in mice. In the present study, we used intact human colon tissue in organ culture to compare responses initiated
Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 46(2), 114-122 (2009-11-17)
Normal and neoplastic human colon tissue obtained at surgery was used to establish conditions for organ culture. Optimal conditions included an atmosphere of 5% CO2 and 95% O2; tissue partially submerged with mucosa at the gas interface; and serum-free medium
Dan Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6349-6355 (2020-03-12)
A combined analytical, theoretical, and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in pulmonary injuries associated with using
Role of vitamin E-acetate on cisplatin induced genotoxicity: An in vivo analysis
Mazumdar M, et al.,
Central European Journal of Biology, 7(2), 334-342 (2012)
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Importance and uses of vitamin E (tocopherol) in serum-free eukaryotic, including hybridoma and chinese hamster ovary (CHO), cell cultures.

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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