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Merck
CN

T1016

Trichlormethiazide

≥98%

Synonym(s):

6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
(+/-)-, NSC 61560

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About This Item

Empirical Formula (Hill Notation):
C8H8Cl3N3O4S2
CAS Number:
133-67-5
Molecular Weight:
380.66
NACRES:
NA.25
PubChem Substance ID:
24899924
UNSPSC Code:
12352200
EC Number:
205-118-8
MDL number:
MFCD00057315

Key Documents

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InChI key

LMJSLTNSBFUCMU-UHFFFAOYSA-N

InChI

1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)

SMILES string

NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl

assay

≥98%

Quality Level

100

Gene Information

human ... SLC12A3(6559)

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBP8847V
BCBP8847
BCBP7836
BCBP4919
BCBN5940

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Yasuo Takahashi et al.
Cardiovascular diabetology, 10, 45-45 (2011-05-25)
Trichlormethiazide, a thiazide diuretic, was introduced in 1960 and remains one of the most frequently used diuretics for treating hypertension in Japan. While numerous clinical trials have indicated important side effects of thiazides, e.g., adverse effects on electrolytes and uric
Takeshi Takami
Hypertension research : official journal of the Japanese Society of Hypertension, 32(12), 1086-1090 (2009-09-26)
Morning hypertension has been reported to be an important risk factor for cardiovascular events, and arterial stiffness bears a relationship with cardiovascular risk. The aim of this study was to evaluate whether high-dose angiotensin II receptor blocker (ARB) treatment has
Haruo Mizuno et al.
Endocrine, 24(1), 55-59 (2004-07-14)
Congenital nephrogenic diabetes insipidus (NDI) is characterized by the insensitivity of the distal nephron to arginine vasopressin. Clinical knowledge of this disease is based largely on case reports. For this study, we investigated the clinical findings of eight patients in
Osamu Ito et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 26(6), 509-513 (2003-07-17)
Exercise-induced acute renal failure (ARF) developed in a 45-year-old man during antihypertensive therapy with losartan and trichlormethiazide. The antihypertensive therapy was stopped and marked hypouricemia became apparent during improvement of his renal function. The daily urinary excretion of uric acid
Madori Osawa et al.
Pediatric nephrology (Berlin, Germany), 28(9), 1881-1884 (2013-05-22)
Four genes responsible for pseudohypoaldosteronism type II (PHA-II) have been identified, thereby facilitating molecular diagnostic testing. A 1-year-old boy with prolonged hyperkalemia, metabolic acidosis, hyperchloremia, growth delay, and mild hypertension was diagnosed with PHA-II based on the detection of exon
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