T0656
1,3,4,6-Tetrachloro-3α,6α-diphenylglycouril
Synonym(s):
Iodo-Gen®, NSC 4462
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About This Item
Empirical Formula (Hill Notation):
C16H10Cl4N4O2
CAS Number:
Molecular Weight:
432.09
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.22
storage temp.
2-8°C
Quality Level
SMILES string
ClN1C(=O)N(Cl)C2(N(Cl)C(=O)N(Cl)C12c3ccccc3)c4ccccc4
InChI
1S/C16H10Cl4N4O2/c17-21-13(25)23(19)16(12-9-5-2-6-10-12)15(21,11-7-3-1-4-8-11)22(18)14(26)24(16)20/h1-10H
InChI key
FJQZXCPWAGYPSD-UHFFFAOYSA-N
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Related Categories
Application
Iodination reagent used in radioiodination acting as an oxidative agent
Reagent involved in comparison studies with chloramine-T
Reagent used for oxidation of urazoles
Reagent involved in comparison studies with chloramine-T
Reagent used for oxidation of urazoles
Legal Information
Iodo-Gen is a registered trademark of Pierce Biotechnology, Inc.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Bernard M Tijink et al.
European journal of nuclear medicine and molecular imaging, 36(8), 1235-1244 (2009-03-05)
The human monoclonal antibody (MAb) fragment L19-SIP is directed against extra domain B (ED-B) of fibronectin, a marker of tumour angiogenesis. A clinical radioimmunotherapy (RIT) trial with (131)I-L19-SIP was recently started. In the present study, after GMP production of (124)I
Th M Behr et al.
Nuklearmedizin. Nuclear medicine, 41(2), 71-79 (2002-05-07)
Simple and reliable methodologies for radioiodination of proteins and peptides are described. The labeling systems are easy to assemble, capable of radioiodinating any protein or, with slight modifications, also peptide (molecular mass 1000-300,000) from kBq to GBq levels of activity
Miro J Eigenmann et al.
The Journal of physiology, 595(24), 7311-7330 (2017-09-30)
For therapeutic antibodies, total tissue concentrations are frequently reported as a lump sum measure of the antibody in residual plasma, interstitial fluid and cells. In terms of correlating antibody exposure to a therapeutic effect, however, interstitial pharmacokinetics might be more
Ulla Lund et al.
American journal of physiology. Renal physiology, 284(6), F1226-F1234 (2003-03-07)
The size and charge-selective properties of the glomerular barrier are partly controversial. Glomerular sieving coefficients (theta) for proteins have rarely been determined noninvasively before in vivo. Therefore, theta was assessed vs. glomerular filtration rate (GFR; (51)Cr-EDTA clearance) in intact rats
Helge Wiig et al.
The Journal of physiology, 567(Pt 2), 557-567 (2005-07-05)
Knowledge of macromolecular distribution volumes is essential in understanding fluid transport within normal and pathological tissues. In this study in vivo we determined the distribution volumes of several macromolecules, including one monoclonal antibody, in tumours and tested whether charges associated
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