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Merck
CN

T0273

N-p-Tosyl-Gly-Pro-Arg 7-amido-4-methylcoumarin hydrochloride

protease substrate

Synonym(s):

N-(p-Tosyl)-Gly-Pro-Arg-AMC, Tos-Gly-Pro-Arg-AMC

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About This Item

Empirical Formula (Hill Notation):
C30H37N7O7S · HCl
CAS Number:
117961-27-0
Molecular Weight:
676.18
NACRES:
NA.32
PubChem Substance ID:
24899877
UNSPSC Code:
12352204
MDL number:
MFCD00152182

Key Documents

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Product Name

N-p-Tosyl-Gly-Pro-Arg 7-amido-4-methylcoumarin hydrochloride, protease substrate

InChI

1S/C30H37N7O7S.ClH/c1-18-7-10-21(11-8-18)45(42,43)34-17-26(38)37-14-4-6-24(37)29(41)36-23(5-3-13-33-30(31)32)28(40)35-20-9-12-22-19(2)15-27(39)44-25(22)16-20;/h7-12,15-16,23-24,34H,3-6,13-14,17H2,1-2H3,(H,35,40)(H,36,41)(H4,31,32,33);1H/t23-,24-;/m0./s1

SMILES string

Cl.Cc1ccc(cc1)S(=O)(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc3ccc4C(C)=CC(=O)Oc4c3

InChI key

SRRKKDQGNHCPIE-UKOKCHKQSA-N

assay

≥98% (TLC)

form

powder

solubility

acetic acid: 10 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000432605
0000432605
0000356712
0000356712
SLCB5102

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V A Kuznetsov et al.
Laboratornoe delo, (8)(8), 43-45 (1990-01-01)
Toz-Gly-Pro-Arg-4-methylcoumaryl-7-amide is recommended for antithrombin-III (AT-III) photometry as a substrate. This substrate is cleaved by thrombin at 366 nm. AT-III photometry with this substrate is in accord with the requirements to methods used in clinical laboratory diagnosis, and the results
A Pasternak et al.
Biochemistry, 37(46), 16201-16210 (1998-11-18)
The zymogen and mature enzyme forms of trypsin-like serine proteases exhibit a wide range of activities. The prototypical trypsinogen-trypsin system is an example of a minimally active zymogen and a maximally active mature protease. The present work identifies several features
Efrat Shavit-Stein et al.
Frontiers in neurology, 9, 1139-1139 (2019-01-22)
Thrombin and its protease-activated receptor 1 (PAR1) are potentially important in peripheral nerve inflammatory diseases. We studied the role of thrombin and PAR1 in rat experimental autoimmune neuritis (EAN), a model of the human Guillain-Barré syndrome (GBS). EAN was induced
Efrat Shavit-Stein et al.
PloS one, 14(7), e0219453-e0219453 (2019-07-06)
Diabetic neuropathy is common and disabling despite glycemic control. Novel neuroprotective approaches are needed. Thrombin and hypercoagulability are associated with diabetes and nerve conduction dysfunction. Our aim was to study the role of thrombin in diabetic neuropathy. We measured thrombin

Protocols

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

牛血浆凝血酶

凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。

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