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Assay
≥95% (reversed phase HPLC)
form
buffered aqueous solution
specific activity
5 U/μL
mol wt
60 kDa
NCBI accession no.
storage temp.
2-8°C
Application
Study enzyme kinetics and screen for inhibitors.
Biochem/physiol Actions
Tyrosinase is a copper-containing enzyme that catalyzes four steps in the melanin and catecholamine synthesis pathways. It catalyzes the formation of L-DOPA (L-3,4-dihydroxyphenylalanine) in the brain and nervous system. It oxidizes monophenols and o-diphenols to o-quinones. The molecular mass is approximately 60 kDa.
Unit Definition
One unit will produce 100 picomoles of dopachrome-MBTH adduct from L-tyrosine per minute at pH 7.3 at 37 °C.
Physical form
Supplied in 30mM NaPO4, pH 6.8
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
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Daniela Murtas et al.
Histochemistry and cell biology, 151(2), 175-185 (2018-09-21)
While histological analysis represents a powerful tool for the classification of melanocytic lesions as benign or malignant, a clear-cut distinction between a nevus and a melanoma is sometimes a challenging step of the diagnostic process. The immunohistochemical detection of tyrosinase
Atsushi Ishihara et al.
Bioscience, biotechnology, and biochemistry, 82(1), 22-30 (2018-01-04)
Tyrosinase is the key enzyme that controls melanin formation in the human skin. We performed a screening of 96 extracts of mushroom cultures and fruiting bodies for examining their inhibitory activity against mushroom tyrosinase. The ethyl acetate extracts of culture
Michele Schlich et al.
Colloids and surfaces. B, Biointerfaces, 171, 675-681 (2018-08-15)
Tyrosinase is one of the key enzymes in mammalian melanin biosynthesis. Decreasing tyrosinase activity has been targeted for the prevention of conditions related to the hyperpigmentation of the skin, such as melasma and age spots. This paper is devoted to
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