SRP8045
CD40L, Soluble mouse
recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
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Synonym(s):
ACRP30headless:CD154, ACRP30headless:CD40L, ACRP30headless:TNFSF5, ADIPOQ-CD40L
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
mouse
recombinant
expressed in CHO cells
tag
FLAG® tagged
Assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
35-40 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<0.01 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Cd40lg(21947)
General description
CD40L (cluster of differentiation 40 ligand), a member of TNF (tumor necrosis factor) superfamily, is a membrane bound protein. This protein is predominantly expressed transiently by activated CD4+ T cells either as a cell-surface molecule or a secreted multimer protein. Activated B cells, certain DC (dendritic cell) subsets, platelets, and smooth muscle cells also express this protein.
Biochem/physiol Actions
CD40L (cluster of differentiation 40 ligand) interacts with its receptor CD40 which in turn helps mediate the interaction between APCs (antigen presenting cells) and lymphocytes. Activated platelets produce CD40L which then participates in multiple processes such as endothelial cell reactions, formation of germinal center, T-helper cell priming, and cytotoxic T-cell activation. Platelets are also involved in the pathogenesis of asthma through CD40L where they inhibit the production of regulatory T-cells and promote polarization of T-helper cells. Studies in mice show that this protein confers protection against influenza virus, though in a CD4+ T cell independent manner.
Physical form
Lyophilized from PBS.
Reconstitution
Reconstitute with 100 μL deionized water.
Other Notes
Mouse CD40L (aa 115-260) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Anwar M Hashem et al.
Journal of immunology (Baltimore, Md. : 1950), 193(2), 722-734 (2014-06-15)
CD40L, a key regulator of the immune system, was studied as both a targeting ligand and a molecular adjuvant in nucleoprotein (NP)-based host defense against influenza in mouse models with different genetic backgrounds. Adenoviral vectors secreting NP-CD40L fusion protein (denoted
Jun Tian et al.
Cellular & molecular immunology, 12(6), 700-707 (2014-11-25)
Platelet activation is associated with multiple immune responses and the pathogenesis of various immune-related diseases. However, the exact role and the underlying mechanism of platelets in the progression of allergic asthma remain largely unclear. In this study, we demonstrate that
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