SRP8044
CD40L, Soluble human
recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
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Synonym(s):
ACRP30headless:CD154, ACRP30headless:CD40L, ACRP30headless:TNFSF5, ADIPOQ-CD40L
UNSPSC Code:
12352200
NACRES:
NA.77
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biological source
human
recombinant
expressed in CHO cells
tag
FLAG® tagged
Assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
35-40 kDa by SDS-PAGE
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<0.01 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CD40LG(959)
General description
CD40L (cluster of differentiation 40 ligand) belongs to the tumor necrosis factor (TNF) family, and is expressed by basophils, B cells, monocytic cells, natural killer cells, platelets, mast cells and T cells. It is predominantly expressed on pro-inflammatory T cells. It also exists in a soluble form.
Biochem/physiol Actions
CD40L (cluster of differentiation 40 ligand) is active in its membrane-bound form. It interacts with CD40 and functions as a proinflammatory and procoagulant agent. The serum levels of soluble CD40L is elevated in malignant middle cerebral artery infarction (MMCAI) patients, especially in non-surviving patients.
Physical form
Lyophilized from PBS
Reconstitution
Reconstitute with 100 μL deionized water.
Other Notes
Human CD40L (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Association between Serum Soluble CD154 Levels and Mortality in Patients with Malignant Middle Cerebral Artery Infarction.
Lorente L, et al.
International Journal of Molecular Sciences, 16(6), 12147-12158 (2015)
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex.
Holler N, et al.
Molecular and Cellular Biology, 23(4), 1428-1440 (2003)
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