SRP8001
Calreticulin human
recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
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Synonym(s):
CRP55, Calregulin, ERp60, Endoplasmic reticulum resident protein 60, grp60
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in E. coli
tag
His tagged
Assay
>90% (SDS-PAGE)
form
liquid
mol wt
~55 kDa by SDS-PAGE
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
calcium flux assay: suitable
impurities
<1 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CALR(811)
General description
Calreticulin (CALR) is expressed in the endoplasmic reticulum. The gene encoding it is localized on human chromosome 19p13.13.
Application
Human calreticulin has been used in a study to determine the effects of uncoupling protein 4 (UCP4) on the expression of proteins in the store-operated Ca2+ entry pathway.
Biochem/physiol Actions
Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the ′calreticulin/calnexin cycle′ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.
Physical form
Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.
Other Notes
Human calreticulin (aa18-417) is fused at the C-terminus to a His-tag.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
Certificates of Analysis (COA)
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Type 1 versus Type 2 calreticulin mutations in essential thrombocythemia: a collaborative study of 1027 patients
Ayalew Tefferi
American Journal of Hematology, 89 (2014)
A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation.
Kollmann K
Leukemia, 31(4) (2017)
CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis
Elisa Rumi
Blood, 123 (2014)
Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrin ?1.
Yamamoto M
Endocrinology (2017)
New microdeletion and microduplication syndromes: a comprehensive review
Julian Nevado
Genetics and Molecular Biology (2014)
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