SRP6561
Cathepsin K Active human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
CTSK, CTSO, CTSO3
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
biological source
human
recombinant
expressed in E. coli
Assay
≥90% (SDS-PAGE)
form
liquid
mol wt
23.5 kDa (115-329 aa)
packaging
pkg of 5 μg
pkg of 50 μg
concentration
0.5 mg/mL
technique(s)
activity assay: suitable
suitability
suitable for molecular biology
UniProt accession no.
application(s)
life science and biopharma
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CTSK(1513)
General description
Cathepsin K is expressed as procathepsin K, which is the inactive proenzyme of cathepsin K. Cathepsin K is a lysosomal cysteine protease and part of the papain cysteine protease family. It is expressed in osteoclasts. The gene encoding this protein is localized on human chromosome 1q21.
Biochem/physiol Actions
Cathepsin K has a role in bone resorption and remodeling. It has a triple helical collagen hydrolase activity. Mutations in the gene encoding this protein have been linked to pycnodysostosis.
Physical form
0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Cathepsin K as a biomarker of bone involvement in type 1 Gaucher disease.
Bobillo L J, et al.
Medicina clinica, 145(7), 281-287 (2015)
Increased Circulating Cathepsin K in Patients with Chronic Heart Failure.
Zhao G, et al.
PLoS ONE, 10(8), e0136093-e0136093 (2015)
Andrew Wieczorek et al.
BMC biotechnology, 15, 112-112 (2015-12-17)
Triple helical collagens are the most abundant structural protein in vertebrates and are widely used as biomaterials for a variety of applications including drug delivery and cellular and tissue engineering. In these applications, the mechanics of this hierarchically structured protein
A Mutation in CTSK Gene in an Autosomal Recessive Pycnodysostosis Family of Chinese Origin.
Huang X, et al.
Calcified Tissue International, 96(5), 373-378 (2015)
Autocatalytic activation of human cathepsin K.
McQueney M S, et al.
The Journal of Biological Chemistry, 272(21), 13955-13960 (1997)
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