SRP6558
Cathepsin K Active from mouse
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
CTSK, CTSO, CTSO3
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
mouse
recombinant
expressed in E. coli
Assay
≥90% (SDS-PAGE)
form
liquid
mol wt
23.4 kDa (115-329 aa)
packaging
pkg of 5 μg
pkg of 50 μg
concentration
0.5 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... CTSK(13038)
General description
Cathepsin K belongs to the peptidase C1 protein family and is a lysosomal cysteine protease. The associated gene is strongly expressed on osteoclasts and is also present in cardiomyocytes. Cathepsin K is the most abundant and main protease involved with osteoclastic activity.
Biochem/physiol Actions
Cathepsin K is responsible for collagenolytic and elastolytic activities. It can degrade type II collagen and thus participates in the degradation of articular cartilage. It also plays an important role in osteoarthritis and periodontitis. Removal of the cathepsin K activity provides protection against agents inducing metabolic stress in the heart. Absence of cathepsin K also protects from age-related decline in cardiac function by inhibition of caspase-associated and caspase-independent cell death.
Physical form
0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy.
Hua Y, et al.
Hypertension, 61, 1184-1184 (2013)
Cathepsin K knockout alleviates aging-induced cardiac dysfunction.
Hua Y, et al.
Aging Cell, 14, 345-345 (2015)
In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis.
Satkunananthan PB, et al.
Osteoarthritis and Cartilage, 22, 1461-1461 (2014)
Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role.
Hao L, et al.
Febs Letters, 589, 1331-1331 (2015)
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